The availability of full match sibling donors and feasibility of allogeneic bone marrow transplantation in Brazil

Autor: Gislaine B. Oliveira, Afonso Celso Vigorito, Katia A.B. Eid, F.J.P. Aranha, C.A. De Souza, E.C.M. Miranda
Rok vydání: 2003
Předmět:
Adult
Male
medicine.medical_specialty
Adolescent
Physiology
Immunology
Biophysics
Developing country
Allogeneic bone marrow transplantation
Selection of donors
Biochemistry
Internal medicine
Living Donors
medicine
Humans
Transplantation
Homologous
General Pharmacology
Toxicology and Pharmaceutics
Sibling
Child
Bone Marrow Diseases
lcsh:QH301-705.5
Survival rate
Bone Marrow Transplantation
Retrospective Studies
lcsh:R5-920
Hematology
Social and economic conditions
business.industry
Siblings
General Neuroscience
Myeloid leukemia
Retrospective cohort study
Cell Biology
General Medicine
Middle Aged
Histocompatibility
Surgery
Survival Rate
Transplantation
Socioeconomic Factors
lcsh:Biology (General)
Child
Preschool
Educational Status
Feasibility Studies
Female
lcsh:Medicine (General)
business
Brazil
Zdroj: Brazilian Journal of Medical and Biological Research, Vol 36, Iss 3, Pp 315-321 (2003)
Brazilian Journal of Medical and Biological Research v.36 n.3 2003
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Brazilian Journal of Medical and Biological Research, Volume: 36, Issue: 3, Pages: 315-321, Published: MAR 2003
ISSN: 0100-879X
DOI: 10.1590/s0100-879x2003000300005
Popis: The feasibility of allogeneic bone marrow transplantation (alloBMT) in a developing country has not yet been demonstrated. Many adverse factors including social and economic limitations may reduce the overall results of this complex and expensive procedure. Our objective was to characterize the most important clinical, social and economic features of candidates for transplantation and their potential donors as well as the influence of these factors on overall survival in a retrospective and exploratory analysis at a university hospital. From July 1993 to July 2001, candidates for BMT were referred to the Bone Marrow Transplantation Unit by Hematology and Oncology Centers from several regions of Brazil. A total of 1138 patients were referred to us as candidates for alloBMT. Median age was 25 years (range: 2 months-60 years), 684 (60.1%) were males and 454 (39.9%) were females. The clinical indications were severe aplastic anemia and hematological malignancies. From the total of 1138 patients, 923 had HLA-typing; 497/923 (53.8%) candidates had full match donors; 352/1138 (30.8%) were eligible for alloBMT. Only 235 of 352 (66.7%) were transplanted. Schooling was 1st to 8th grade for 123/235 (52.3%); monthly family income ranged from US$60 (7%) to more than US$400 (36%). Overall survival for patients with chronic myeloid leukemia, severe aplastic anemia and acute myeloid leukemia was 58, 60 and 30%, respectively. Thus, overall survival rates for the most frequent hematological diseases were similar to those reported in the International Registry, except for acute myeloid leukemia. This descriptive and exploratory analysis suggests the feasibility of alloBMT in a developing country like Brazil.
Databáze: OpenAIRE
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