Intraperitoneal Administration of Muramyl Dipeptide β-Heptylglycoside to Pregnant and Non-Pregnant Female Mice Modulates Production of Th1/Th2/Th17/Tr1 Cytokines by Splenocytes Ex Vivo
| Autor: | L. I. Vinnitskii, K. A. Bunyatyan, M. N. Boltovskaya, O V Kalyuzhin, E. V. Inviyayeva, Alexander Karaulov, K. A. Artem’eva |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Biology General Biochemistry Genetics and Molecular Biology Andrology Interferon-gamma Mice chemistry.chemical_compound Adjuvants Immunologic Pregnancy Splenocyte medicine Animals Secretion Mating Cells Cultured Crosses Genetic reproductive and urinary physiology Mice Inbred BALB C Tumor Necrosis Factor-alpha Interleukins Glycopeptides Granulocyte-Macrophage Colony-Stimulating Factor General Medicine medicine.disease Lymphocyte Subsets Abortion Spontaneous Disease Models Animal chemistry Mice Inbred DBA Immunology Embryo Loss Mice Inbred CBA Cytokines Gestation Female Tumor necrosis factor alpha Injections Intraperitoneal Spleen Muramyl dipeptide Ex vivo |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 159:53-57 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-015-2888-7 |
| Popis: | Muramyl dipeptide β-heptylglycoside (C7MDP) was administered to non-pregnant CBA female mice and pregnant mice after non-abortion-prone mating (CBA×BALB/c) and mating associated with a high rate of spontaneous abortion (CBA×DBA/2). In non-pregnant females, C7MDP increased the production of IL-2, IL-4, IL-5, IL-6, IL-17, IFNγ, TNFα, and GM-CSF at constant production of IL-1α and IL-10. C7MDP increased the production of IL-10 and IL-17 and suppressed the production of IFNγ on day 8 of gestation in non-abortion-prone mouse couples and stimulated the synthesis of IL-4 and IFNγ, reduced IL-5 production, and slightly increased IL-1α secretion after abortion-prone mating. On day 14 of gestation, C7MDP elevated the yield of IL-2, IL-4, IFNγ, TNFα, and GM-CSF in CBA×BALB/c and CBA×DBA/2 couples and IL-17 in the fi rst variant of mating. |
| Databáze: | OpenAIRE |
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