Cedratvirus, a Double-Cork Structured Giant Virus, is a Distant Relative of Pithoviruses
| Autor: | Jacques Yaacoub Bou Khalil, Sarah Aherfi, Fabrizio Di Pinto, Didier Raoult, Idir Bitam, Bernard La Scola, Julien Andreani, Philippe Colson |
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| Přispěvatelé: | Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Assistance Publique - Hôpitaux de Marseille (APHM), Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
viral family
0301 basic medicine giant viruses Cedratvirus Pithovirus double-cork co-culture Acanthamoeba lcsh:QR1-502 Genome Viral Genome Article lcsh:Microbiology 03 medical and health sciences Phylogenetics [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Virology Environmental Microbiology Giant Virus Phylogeny Genetics Comparative genomics Acanthamoeba castellanii Mimivirus biology Virion Sequence Analysis DNA biology.organism_classification 3. Good health 030104 developmental biology Infectious Diseases Algeria DNA Viral [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology |
| Zdroj: | Viruses; Volume 8; Issue 11; Pages: 300 Viruses Viruses, MDPI, 2016, 8 (11), ⟨10.3390/v8110300⟩ Viruses, Vol 8, Iss 11, p 300 (2016) Viruses, 2016, 8 (11), ⟨10.3390/v8110300⟩ |
| ISSN: | 1999-4915 |
| DOI: | 10.3390/v8110300 |
| Popis: | International audience; Most viruses are known for the ability to cause symptomatic diseases in humans and other animals. The discovery of Acanthamoeba polyphaga mimivirus and other giant amoebal viruses revealed a considerable and previously unknown area of uncharacterized viral particles. Giant viruses have been isolated from various environmental samples collected from very distant geographic places, revealing a ubiquitous distribution. Their morphological and genomic features are fundamental elements for classifying them. Herein, we report the isolation and draft genome of Cedratvirus, a new amoebal giant virus isolated in Acanthamoeba castellanii, from an Algerian environmental sample. The viral particles are ovoid-shaped, resembling Pithovirus sibericum, but differing notably in the presence of two corks at each extremity of the virion. The draft genome of Cedratvirus589,068 base pairs in lengthis a close relative of the two previously described pithoviruses, sharing 104 and 113 genes with P. sibericum and Pithovirus massiliensis genomes, respectively. Interestingly, analysis of these viruses' core genome reveals that only 21% of Cedratvirus genes are involved in best reciprocal hits with the two pithoviruses. Phylogeny reconstructions and comparative genomics indicate that Cedratvirus is most closely related to pithoviruses, and questions their membership in an enlarged putative Pithoviridae family. |
| Databáze: | OpenAIRE |
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