A Review on Analytical Strategies for the Assessment of Recently Approved Direct Acting Antiviral Drugs
| Autor: | Heba H. Abdine, Mohamed A. Korany, Marwa A.A. Ragab, Sara I. Aboras |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Ledipasvir
Elbasvir Sofosbuvir Voxilaprevir Hepacivirus 02 engineering and technology Computational biology medicine.disease_cause Antiviral Agents 01 natural sciences Analytical Chemistry chemistry.chemical_compound medicine Humans Coronavirus business.industry 010401 analytical chemistry Glecaprevir Hepatitis C Chronic 021001 nanoscience & nanotechnology Pibrentasvir COVID-19 Drug Treatment 0104 chemical sciences Grazoprevir chemistry 0210 nano-technology business medicine.drug |
| Zdroj: | Critical Reviews in Analytical Chemistry. 52:1878-1900 |
| ISSN: | 1547-6510 1040-8347 |
| DOI: | 10.1080/10408347.2021.1923456 |
| Popis: | Human beings are in dire need of developing an efficient treatment against fierce viruses like hepatitis C virus (HCV) and Coronavirus (COVID-19). These viruses have already caused the death of over two million people all over the world. Therefore, over the last years, many direct-acting antiviral drugs (DAADs) were developed targeting nonstructural proteins of these two viruses. Among these DAADs, several drugs were found more effective and safer than the others as sofosbuvir, ledipasvir, grazoprevir, glecaprevir, voxilaprevir, velpatasvir, elbasvir, pibrentasvir and remdesivir. The last one is indicated for COVID-19, while the rest are indicated for HCV treatment. Due to the valuable impact of these DAADs, larger number of analytical methods were required to meet the needs of the clinical studies. Therefore, this review will highlight the current approaches, published in the period between 2017 to present, dealing with the determination of these drugs in two different matrices: pharmaceuticals and biological fluids with the challenges of analyzing these drugs either alone, with other drugs, in presence of interferences (pharmaceutical excipients or endogenous plasma components) or in presence of matrix impurities, degradation products and metabolites. These approaches include spectroscopic, chromatographic, capillary electrophoretic, voltametric and nuclear magnetic resonance methods that have been reported during this period. Moreover, the analytical instrumentation and methods used in determination of these DAADs will be illustrated in tabulated forms. |
| Databáze: | OpenAIRE |
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