Resveratrol treatment improves the altered metabolism and related dysbiosis of gut programed by prenatal high-fat diet and postnatal high-fat diet exposure

Autor: Mao-Meng Tiao, Ching-Chou Tsai, Chih-Po Chiang, I-Chun Lin, Li-Tung Huang, Yi-Chuan Huang, Hong-Ren Yu, You-Lin Tain, Yu-Ju Lin, Chih-Yao Hou, Chih-Cheng Chen, Yao-Tsung Yeh, Jiunn-Ming Sheen
Rok vydání: 2020
Předmět:
0301 basic medicine
Endocrinology
Diabetes and Metabolism
Clinical Biochemistry
Blood Pressure
Resveratrol
Gut flora
Biochemistry
Rats
Sprague-Dawley
chemistry.chemical_compound
0302 clinical medicine
Pregnancy
Lactation
Nutrition and Dietetics
biology
Intestines
medicine.anatomical_structure
Prenatal Exposure Delayed Effects
030220 oncology & carcinogenesis
Female
medicine.medical_specialty
Offspring
Diet
High-Fat
03 medical and health sciences
Internal medicine
medicine
Animals
Weaning
Molecular Biology
business.industry
Body Weight
Polyphenols
Maternal Nutritional Physiological Phenomena
Glucose Tolerance Test
Fatty Acids
Volatile
Lipid Metabolism
biology.organism_classification
medicine.disease
Gastrointestinal Microbiome
Rats
030104 developmental biology
Endocrinology
Gene Expression Regulation
chemistry
Dysbiosis
Metagenome
Metabolic syndrome
business
Zdroj: The Journal of Nutritional Biochemistry. 75:108260
ISSN: 0955-2863
DOI: 10.1016/j.jnutbio.2019.108260
Popis: A maternal high-fat (HF) diet sensitizes offspring to the adverse effects of postnatal HF intake and can lead to metabolic dysregulation. Resveratrol, a natural polyphenolic compound found in grapes and red wine, could help to relieve metabolic syndrome dysregulation. Since the gut microbiota is known to be closely related to metabolic homeostasis, this study aimed to investigate the impact of a combination of maternal and postweaning HF diets on the gut microbiota and whether resveratrol could relieve the gut dysbiosis associated with metabolic dysregulation. Sprague-Dawley dams were sustained on either a chow or HF diet before mating, during pregnancy and during lactation. Their offspring were randomly fed chow or a HF diet after weaning. Four experimental groups were generated: CC (maternal/postnatal chow diet), HC (maternal HF/postnatal chow diet), CH (maternal chow/postnatal high-fat diet) and HH (maternal/postnatal HF diet). A fifth group consisted of HH with resveratrol treatment. We found that both maternal and postnatal HF exposure has a distinct effect on the gut microbiota metagenome of offspring. Maternal HF diet exposure decreased plasma acetate, propionate and butyrate level, while postnatal HF diet exposure decreased plasma acetate level in adult life. The metabolic dysregulation programed by the maternal and postnatal HF diets was related to the relevant gut microbiota. Resveratrol treatment ameliorated the altered plasma propionate level related to maternal HF and postnatal HF diet treatment. Resveratrol treatment also improved most of the altered metabolic dysregulation and related dysbiosis programmed by maternal and postnatal HF diet exposure.
Databáze: OpenAIRE
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