In-vivo tongue stiffness measured by aspiration: Resting vs general anesthesia

Autor: S. Boonstra, Seyed Ali Elahi, Nathanaël Connesson, Yohan Payan, K.D.R. Kappert, A.J.M. Balm, F. van der Heijden
Přispěvatelé: Netherlands Cancer Institute (NKI), Antoni van Leeuwenhoek Hospital, Ingénierie Biomédicale et Mécanique des Matériaux (TIMC-IMAG-BioMMat), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Gestes Medico-chirurgicaux Assistés par Ordinateur (TIMC-GMCAO), Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 (TIMC ), University of Amsterdam [Amsterdam] (UvA), University of Twente [Netherlands], Robotics and Mechatronics
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Yeoh
0206 medical engineering
Finite Element Analysis
UT-Hybrid-D
Biomedical Engineering
Biophysics
General anesthesia
02 engineering and technology
Anesthesia
General
Tongue stiffness
03 medical and health sciences
Muscle tone
0302 clinical medicine
Swallowing
Tongue
Elastic Modulus
Medicine
Humans
Orthopedics and Sports Medicine
[PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph]
Mastication
Tongue cancer
business.industry
Tissue parameters
Rehabilitation
Work (physics)
Stiffness
[SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph]
Aspiration device
Blood flow
020601 biomedical engineering
Biomechanical Phenomena
medicine.anatomical_structure
Anesthesia
[SDV.IB]Life Sciences [q-bio]/Bioengineering
medicine.symptom
business
030217 neurology & neurosurgery
Zdroj: Journal of Biomechanics
Journal of Biomechanics, Elsevier, 2020, 114, pp.110147. ⟨10.1016/j.jbiomech.2020.110147⟩
Journal of biomechanics, 114:110147. Elsevier
ISSN: 0021-9290
Popis: Tongue cancer treatment often results in impaired speech, swallowing, or mastication. Simulating the effect of treatments can help the patient and the treating physician to understand the effects and impact of the intervention. To simulate deformations of the tongue, identifying accurate mechanical properties of tissue is essential. However, not many succeeded in characterizing in-vivo tongue stiffness. Those who did, measured the tongue At Rest (AR), in which muscle tone subsides even if muscles are not willingly activated. We expected to find an absolute rest state in participants 'under General Anesthesia' (GA). We elaborated on previous work by measuring the mechanical behavior of the in-vivo tongue under aspiration using an improved volume-based method. Using this technique, 5 to 7 measurements were performed on 10 participants both AR and under GA. The obtained Pressure-Shape curves were first analyzed using the initial slope and its variations. Hereafter, an inverse Finite Element Analysis (FEA) was applied to identify the mechanical parameters using the Yeoh, Gent, and Ogden hyperelastic models. The measurements AR provided a mean Young's Modulus of 1638 Pa (min 1035 - max 2019) using the Yeoh constitutive model, which is in line with previous ex-vivo measurements. However, while hoping to find a rest state under GA, the tongue unexpectedly appeared to be approximately 2 to 2.5 times stiffer under GA than AR. Explanations for this were sought by examining drugs administered during GA, blood flow, perfusion, and upper airway reflexes, but neither of these explanations could be confirmed. ispartof: JOURNAL OF BIOMECHANICS vol:114 ispartof: location:United States status: published
Databáze: OpenAIRE
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