The effect of age on the hydroxylation of amylobarbitone sodium in man

Autor:	J.R. Trounce, R. E. Irvine, J. Grove, P.A. Toseland
Rok vydání:	2012
Předmět:	Pharmacology Amylobarbitone sodium medicine.medical_specialty business.industry Plasma levels Single oral dose Hydroxylation chemistry.chemical_compound Endocrinology chemistry Internal medicine Papers medicine Pharmacology (medical) business
Zdroj:	British journal of clinical pharmacology. 1(1)
ISSN:	0306-5251
Popis:	1 Following a single oral dose of amylobarbitone sodium it has been shown that a group of young subjects convert a higher proportion of the dose to 3′-hydroxyamylobarbitone than a group of elderly subjects. 2 Twenty-four hours after the administration of the drug, the mean plasma level of amylobarbitone in the elderly group is significantly higher than in the group of young subjects. 3 It is concluded that the rate of hydroxylation of amylobarbitone sodium decreases with age.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15365023bddd0d578eace2d03534f80d https://pubmed.ncbi.nlm.nih.gov/22454867 Zobrazit plný text záznamu Plný text