Role of parenteral iron in transfusion requirements after total hip replacement. A pilot study
| Autor: | J. Seara, Enrique Naveira, J. Cuenca, Manuel Muñoz, José Antonio García-Erce, J H Palmer |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Blood transfusion Arthroplasty Replacement Hip medicine.medical_treatment Pilot Projects Iron sucrose Ferric Compounds law.invention Glucaric Acid Randomized controlled trial law Humans Medicine Blood Transfusion Infusions Parenteral Aged Retrospective Studies Aged 80 and over Ferric Oxide Saccharated business.industry Anemia Retrospective cohort study Hematology Arthroplasty Clinical trial Anesthesia Erythropoiesis Female Implant business medicine.drug |
| Zdroj: | Transfusion Medicine. 16:137-142 |
| ISSN: | 1365-3148 0958-7578 |
| DOI: | 10.1111/j.1365-3148.2005.00629.x |
| Popis: | An important percentage of patients undergoing total hip replacement (THR) receive allogeneic blood transfusion (ABT) to avoid the risks of acute anaemia. However, concerns about the risks of ABT have led to the search for alternatives, such as stimulation of erythropoiesis. We prospectively investigated the effect of postoperative administration of 300 mg of intravenous iron sucrose on ABT requirements in THR patients (group 2; n = 24). A previous series of 22 THR patients served as the control group (group 1). All patients were operated on by the same surgeon, using the same implant, and a set of clinical data was gathered. No adverse reactions to iron administration were observed. The group-given iron showed a trend to a lower transfusion rate (46 vs. 73%; P = 0.067) and lower transfusion index (0.96 vs. 1.68 units/patient; P = 0.038). Moreover, amongst the non-transfused patients, admission haemoglobin levels were lower in those coming from the iron group than those from the control group (12.7 +/- 0.9 vs. 14.0 +/- 1.2 g dL(-1), respectively; P = 0.017). Postoperative parenteral iron administration could be a safe and effective way to reduce ABT requirements in the THR patients. A large, randomized controlled trial to confirm these results is warranted. |
| Databáze: | OpenAIRE |
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