An integrated model for the glucose-insulin system
| Autor: | Petra M. Jauslin, Hanna E. Silber, Mats O. Karlsson, Nicolas Frey |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Blood Glucose
medicine.medical_specialty medicine.medical_treatment Provocation test Carbohydrate metabolism Toxicology Models Biological Internal medicine Diabetes mellitus Insulin Secretion medicine Homeostasis Humans Hypoglycemic Agents Insulin Computer Simulation Pharmaceutical sciences Pancreatic hormone Pharmacology Glycated Hemoglobin Glucose tolerance test medicine.diagnostic_test business.industry General Medicine Glucose Tolerance Test medicine.disease Endocrinology Glucose Diabetes Mellitus Type 2 business |
| Zdroj: | Basicclinical pharmacologytoxicology. 106(3) |
| ISSN: | 1742-7843 |
| Popis: | The integrated glucose-insulin model was originally developed on a variety of intravenous glucose provocation experiments in healthy volunteers and type 2 diabetic patients. The model, which simultaneously describes time-courses of glucose and insulin based on mechanism-based components for production, elimination and homeostatic feedback, has been further extended to oral glucose provocations, meal tests and insulin administration. The model has been used to describe experiments ranging from 4 to 24 hr. Applications of the integrated glucose-insulin model include the clinical assessment of the mechanism of action of anti-diabetic drugs and the magnitude of their effects. Finally, the model was used for optimizing the design of provocation experiments. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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