High frequency of upper aerodigestive tract manifestations in mucous membrane pemphigoid
| Autor: | Shigeo Tanaka, Hideo Niwa, Terry D. Rees, Morio Iijima, Hiroyasu Endo, Masamichi Komiya, Kayo Kuyama, Tae Serizawa, Maya Oshima |
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| Rok vydání: | 2021 |
| Předmět: |
Pemphigoid
medicine.medical_specialty Pemphigoid Benign Mucous Membrane Gastroenterology Asymptomatic law.invention 03 medical and health sciences 0302 clinical medicine law Internal medicine Pemphigoid Bullous medicine Fiberscope Humans General Dentistry Direct fluorescent antibody Retrospective Studies Mucous Membrane business.industry 030206 dentistry medicine.disease Gingivitis Immunoglobulin A Desquamative gingivitis Upper aerodigestive tract Otorhinolaryngology Mucous membrane pemphigoid 030220 oncology & carcinogenesis medicine.symptom business Gingival disease |
| Zdroj: | Oral diseasesREFERENCES. 28(6) |
| ISSN: | 1601-0825 |
| Popis: | Objective The objective of this study was to evaluate the frequency of upper aerodigestive tract involvement in patients with mucous membrane pemphigoid associated with desquamative gingivitis. Subjects and methods Data from 25 patients were collected by retrospective chart review. Their upper aerodigestive had been evaluated using a conventional flexible fiberscope. Oral disease activity was quantified on the basis of the Mucous Membrane Pemphigoid Disease Area Index activity score. Results Lesions of the upper aerodigestive tract were confirmed in nine symptomatic patients (9/25, 36%), of which five (5/25, 20%) had laryngeal involvement. No lesions were seen in the asymptomatic patients on fiberscope examination. There was a statistically significant difference in the symptoms, high oral disease activity score, and linear IgA deposition on direct immunofluorescence between patients with and without upper aerodigestive tract lesions (p = .001, .001, .002, respectively). Conclusion The high frequency of considerable complications highlights the importance of confirming the presence of upper aerodigestive tract involvement in patients with mucous membrane pemphigoid having desquamative gingivitis. Signs including the presence of symptoms, high oral disease activity score, or linear IgA deposition on direct immunofluorescence might indicate a higher risk of upper aerodigestive tract involvement. |
| Databáze: | OpenAIRE |
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