Factors predicting decline in renal function and kidney volume growth in autosomal dominant polycystic kidney disease: a prospective cohort study (Japanese Polycystic Kidney Disease registry: J-PKD)
| Autor: | Tadashi Sofue, Akinari Sekine, Kazuhiko Tsuruya, Michihiro Mitobe, Toshio Mochizuki, Yosuke Shimada, Shigeo Horie, Shinya Nakatani, Ken Tsuchiya, Eiji Ishimura, Yoshifumi Ubara, Kazushige Hanaoka, Satoru Muto, Ichiei Narita, Satoshi Tanaka, Shoichi Maruyama, Hiroshi Kataoka, Kiyotaka Uchiyama, Kikuo Nutahara, Saori Nishio, Tatsuya Suwabe |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Blood Glucose Male Nephrology medicine.medical_specialty Physiology 030232 urology & nephrology Autosomal dominant polycystic kidney disease Urology Renal function Kidney Volume 030204 cardiovascular system & hematology Kidney Hemoglobins 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Japan Risk Factors Physiology (medical) Internal medicine medicine Polycystic kidney disease Humans Prospective Studies Registries Prospective cohort study business.industry Cholesterol HDL Age Factors Fasting Organ Size Middle Aged Polycystic Kidney Autosomal Dominant medicine.disease Uric Acid chemistry Disease Progression Uric acid Female business Follow-Up Studies Glomerular Filtration Rate Cohort study |
| Zdroj: | Clinical and Experimental Nephrology. 25:970-980 |
| ISSN: | 1437-7799 1342-1751 |
| DOI: | 10.1007/s10157-021-02068-x |
| Popis: | Factors affecting decline in renal function and cyst growth in patients with autosomal polycystic kidney disease (ADPKD) are not fully described, particularly in Japan. This was the first multi-facility, prospective, observational cohort study conducted in ADPKD patients at 14 centers in Japan. Patients in the J-PKD registry were assessed from December 2009 to June 2012 (follow-up until June 2017). Patients’ data including estimated glomerular filtration rate (eGFR) and total kidney volume (TKV) were assessed initially and a maximum of five times annually. Contributing factors to eGFR decline and TKV growth were identified using multiple linear regression analysis. Of the 340 patients in the J-PKD registry, data analysis was performed for 192 patients in whom serial changes for both eGFR and TKV were obtained. eGFR slope, eGFR change, and TKV change values were as follows: − 2.7 (− 4.2 to − 1.5) (ml/min/1.73 m2/year), − 5.0 (− 9.6 to − 2.3) (%/year), and 4.78 (0.86–8.22) (%/year), respectively. Lower high-density lipoprotein (HDL) cholesterol was an independent predictor of eGFR decline, using both eGFR slope and change (P = 0.04, P = 0.02, respectively), whereas lower hemoglobin and higher uric acid were significantly associated with greater eGFR change only (P = 0.02, P = 0.002, respectively). Younger age and higher fasting blood sugar were independent predictors of greater TKV change (P = 0.01, P = 0.02, respectively). This real-world study in Japan identified risk factors for renal function decline in ADPKD patients. These included lower HDL cholesterol, lower hemoglobin and higher uric acid for eGFR decline, and youth and higher blood sugar levels for TKV growth. |
| Databáze: | OpenAIRE |
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