Placental prothrombin mRNA levels in APC resistance (APCR) women with increased placental fibrin deposition
| Autor: | S. Sedano-Balbas, Majella Maher, Brendan Cleary, Mark Lyons, Margaret Murray, G Gaffney |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
medicine.medical_specialty Placenta Fibrin deposition Fibrin Pregnancy Internal medicine medicine Humans RNA Messenger Activated Protein C Resistance Hemostasis Messenger RNA biology business.industry Apc resistance Placental tissue General Medicine medicine.disease Endocrinology medicine.anatomical_structure Mrna level Immunology biology.protein Female Prothrombin Activated protein C resistance business |
| Zdroj: | Irish Journal of Medical Science (1971 -). 183:477-480 |
| ISSN: | 1863-4362 0021-1265 |
| DOI: | 10.1007/s11845-013-1056-1 |
| Popis: | We investigated the link between the mRNA of the procoagulant prothrombin in the placental tissue with the increased placental fibrin deposition associated with activated protein C resistance (APCR). Women with APCR were not found to produce higher levels of prothrombin transcript compared to women with a normal APC ratio. This indicates that accumulated fibrin in the placenta is not the consequence of too much production of the procoagulant prothrombin transcript, but may be associated with altered function of other haemostatic factors interacting with APC in the placenta. |
| Databáze: | OpenAIRE |
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