In vivo gallbladder bile diffusion coefficient measurement by diffusion-weighted echo planar imaging in hamster fed normal and lithogenic diets

Autor: Claude Lutton, B. Tiffon, Sandrine Dubrac, Andreas Volk, Michel Parquet
Rok vydání: 2000
Předmět:
Zdroj: Magnetic Resonance in Medicine. 43:854-859
ISSN: 1522-2594
0740-3194
DOI: 10.1002/1522-2594(200006)43:6<854::aid-mrm11>3.0.co;2-e
Popis: It is shown that in vivo measurement of bile water apparent diffusion coefficient (ADC) by diffusion-weighted echo-planar imaging (EPI) in hamster gallbladder is possible providing motion artifact-free ADC values. These ADC values are used to estimate bile viscosity variation induced by normal diets, cholesterol gallstone-inducing diets, and an antilithiasic drug, and to determine if a link exists between bile viscosity and cholesterol gallstone formation. Measurements were performed at 4.7 T with respiratory triggering in five groups of hamsters fed a commercial (RC) or a semisynthetic (SSD) diet, a SSD containing 0.2% hyodeoxycholic acid (SSD+HDC) and two lithogenic diets (LD5, LD10). ADC decreased significantly in LD10 (2.15 ± 0.07 × 10−3 mm2s−1) and SSD+HDC (2.03 ± 0.04) compared to RC (2.40 ± 0.05) but not in the most lithogenic LD5 diet (2.33 ± 0.06). No direct relationship was found between bile viscosity and gallstone incidence; however, viscosity seems to be related to lipid contents of diets. Magn Reson Med 43:854–859, 2000. © 2000 Wiley-Liss, Inc.
Databáze: OpenAIRE
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