Technetium-99 m-MDP scintigraphy and long-term follow-up of musculo-skeletal sarcoma reconstructed with pasteurized autologous bone graft
| Autor: | Adel Refaat Ahmed |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent medicine.medical_treatment Bone Neoplasms Sarcoma Ewing Technetium Tc 99m Medronate Bone grafting Osteotomy Scintigraphy Revascularization Transplantation Autologous Bone and Bones Young Adult medicine Humans Internal fixation Orthopedics and Sports Medicine Child Radionuclide Imaging Aged Retrospective Studies Osteosarcoma Bone Transplantation medicine.diagnostic_test business.industry Rotationplasty Sarcoma General Medicine Humerus Middle Aged Plastic Surgery Procedures medicine.disease Surgery Transplantation Radiopharmaceuticals business Follow-Up Studies |
| Zdroj: | Archives of Orthopaedic and Trauma Surgery. 129:475-482 |
| ISSN: | 1434-3916 0936-8051 |
| DOI: | 10.1007/s00402-008-0659-x |
| Popis: | Local bone tumor excision followed by pasteurization and reimplantation is a unique technique of reconstruction for sarcoma patients. The long-term scintigraphic findings of pasteurized bone grafts in relation to clinical patients’ data were reviewed retrospectively. Twenty-two sarcoma patients (mean age, 24 years) done between April 2000 and January 2004 constituted the material of this study. One hundred and fifty-two 99 m TC-methylene diphosphonate (MDP) whole-body scans were reviewed. Initially, all autografts appeared as photon deficient areas. Diffusely increased bone uptake was present at the osteotomy sites within 4–6 months after surgery, the uptake of the grafted pasteurized bone was detected in 17 patients from about 6 months after surgery. Of 22 patients, 11 (50%) showed higher uptake than the normal bone, 6 (27%) had uptake similar to the normal bone, while 5 (23%) had less uptake than the normal bone. Radiologically, 15 patients (68%) showed complete incorporation of graft and 5 patients (23%) had partial incorporation. Oncologically, 16 patients are disease free, while 6 died of disease. No local recurrence was detected at a mean of 59 months, while fracture (13.6%) eventually healed with bone grafting and revision of internal fixation, graft collapse (9%) (needed revision arthroplasty) and infection (9%), one cured and one converted to rotationplasty, were the major complications encountered. Significantly more mechanical complications were seen when tracer uptake suggestive of revascularization occurred; thus, revascularization and partial bone ingrowth are not sufficient conditions for lower mechanical complication rate. The method of pasteurization of bone is a useful option for reconstruction after resection of malignant bone tumors. |
| Databáze: | OpenAIRE |
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