HOTAIR is a REST-regulated lncRNA that promotes neuroendocrine differentiation in castration resistant prostate cancer
| Autor: | Jui Ting Tang, Chin Chen Pan, Ching Hsin Chang, Pei Ching Chang, Tzu-Ping Lin, Yun Li Luo, Mel Campbell, Shih Yen Lu, Tze Tze Liu, Hsing Jein Kung, Yi Ting Chang, Ting Yu Cheng, Chia Pei Yang, Chi Hung Lin |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Cancer Research Biology urologic and male genital diseases Neuroendocrine differentiation 03 medical and health sciences Prostate cancer Downregulation and upregulation Cell Line Tumor medicine Gene silencing Humans Transcription factor Gene knockdown Sequence Analysis RNA HOTAIR Cell Differentiation medicine.disease Neurosecretory Systems Up-Regulation Androgen receptor Gene Expression Regulation Neoplastic Repressor Proteins Prostatic Neoplasms Castration-Resistant 030104 developmental biology Oncology Cancer research Disease Progression RNA Long Noncoding |
| Zdroj: | Cancer letters. 433 |
| ISSN: | 1872-7980 |
| Popis: | Long non-coding RNAs (lncRNAs) are emerging as novel diagnostic markers of prostate cancer (PCa) and new determinants of castration-resistant PCa (CRPC), an aggressive and metastatic form of PCa. In addition to androgen receptor (AR) signaling, neuroendocrine differentiation (NED) is associated with CRPC. Recent reports demonstrate that the downregulation of repressor element-1 silencing transcription factor (REST) protein is a key step in NED of PCa cells. Here, we report HOTAIR as a novel REST-repressed lncRNA that is upregulated in NED PCa cells and in CRPC. HOTAIR overexpression is sufficient to induce, whereas knockdown of HOTAIR suppressed NED of PCa cells. Gene ontology (GO) analysis of differentially expressed genes under HOTAIR overexpression and in CRPC versus benign prostatic hyperplasia (BPH) suggests that HOTAIR may participate in PCa progression. Taken together, our results provide the first evidence of lncRNA HOTAIR as a driver for NED of PCa cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect