Rationally designed chemical modulators convert a bacterial channel protein into a pH-sensory valve
| Autor: | Wim Meijberg, Armagan Kocer, Erik Halza, Bernard Feringa, Erna Bulten, Martin Walko |
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| Přispěvatelé: | TechMed Centre, Molecular Neuroscience and Ageing Research (MOLAR), Synthetic Organic Chemistry |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
ESCHERICHIA-COLI-CELLS
RESIDUE MECHANOSENSITIVE ION-CHANNEL protonation LIPOSOMES Sensory system membrane proteins Biosensing Techniques ACTIVATION Drug Delivery Systems Mechanosensitive ion channel Bacterial Proteins Fluorescent Dyes Chemistry CATALYSIS General Chemistry General Medicine Hydrogen-Ion Concentration Fluoresceins biosensors protein modifications MSCL RECONSTITUTION Biochemistry drug delivery Phosphatidylcholines Biophysics Protons MEMBRANE Communication channel |
| Zdroj: | Angewandte Chemie-International Edition, 45(19), 3126-3130. Wiley Angewandte Chemie-International Edition, 45(19), 3126-3130. WILEY-V C H VERLAG GMBH |
| ISSN: | 1521-3773 1433-7851 |
| Popis: | Open channels: Chemical modulators are developed to convert a naturally occurring channel protein into a pH-actuated nanovalve. The pH interval, sensitivity, and activation of the valve by channel opening are tunable through the design of the modulators. The valve is useful for releasing or mixing the contents of liposomes at a desired location, time, and dosage, for example, in micro/nanosensory and delivery devices (see picture). |
| Databáze: | OpenAIRE |
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