Predominance of Neutrophils in the Cerebrospinal Fluid of AIDS Patients With Cytomegalovirus Radiculopathy
| Autor: | Andrew A. Renshaw, Scott R. Granter, Marc H. Doolittle |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Neutrophils Congenital cytomegalovirus infection medicine.disease_cause Herpesviridae Virus Cerebrospinal fluid Betaherpesvirinae Immunopathology medicine Humans Radiculopathy Sida Cerebrospinal Fluid Retrospective Studies AIDS-Related Opportunistic Infections biology business.industry virus diseases General Medicine Middle Aged Prognosis biology.organism_classification medicine.disease Blood Cell Count Cytomegalovirus Infections Immunology Viral disease business |
| Zdroj: | American Journal of Clinical Pathology. 105:364-366 |
| ISSN: | 1943-7722 0002-9173 |
| DOI: | 10.1093/ajcp/105.3.364 |
| Popis: | Cytomegalovirus (CMV) radiculopathy has been associated with both viral cytopathic inclusions and an increased number of neutrophils in the cerebrospinal fluid (CSF) of patients with AIDS. The significance of these findings is unknown. To evaluate this, the authors reviewed all CSF cytology specimens from patients with a history AIDS or HIV infection over a 9-year period. Of 193 specimens identified, 42 (22%) had neutrophils present. Neutrophils were rare (6 per slide) in the majority of specimens (57%). Occasional neutrophils (2/hpf) were observed in three patients; one with suspected CMV myelitis, one with bacterial meningitis, and one with cryptococcal meningitis. All 6 cases (3 patients) with numerous neutrophils (10/hpf) had positive CMV CSF cultures and symptoms of radiculopathy. Definite viral inclusions were not seen. The prognosis was poor in all cases. The authors conclude that diagnostic CMV inclusions are quite rare. However, the presence of elevated numbers of neutrophils in the CSF of a patient with AIDS without an identified infectious agent is highly suggestive of CMV radiculopathy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|