Which factors influence liver stiffness measured by real-time two dimensional shear wave elastography in patients on maintenance hemodialysis?
| Autor: | Dorotea Božić, Lučana Vicelić Čutura, Danijela Zjacic Puljiz, Iva Jerčić Martinić-Ceza, Željko Puljiz, Ivana Jukić, Kristian Podrug, Marko Puljiz |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Liver Cirrhosis
medicine.medical_specialty Mean arterial pressure Bilirubin Parathyroid hormone chemistry.chemical_compound Renal Dialysis Internal medicine medicine Humans In patient Prospective Studies CHRONIC KIDNEY DISEASE TRANSIENT ELASTOGRAPHY PORTAL HYPERTENSION ULTRASOUND ELASTOGRAPHY CARDIOVASCULAR EVENTS FIBROSIS HEPATITIS CIRRHOSIS AMINOTRANSFERASE DIALYSIS Prospective cohort study Aged Aged 80 and over Shear wave elastography business.industry General Medicine Maintenance hemodialysis Middle Aged Blood pressure chemistry Liver Cardiology Elasticity Imaging Techniques business Research Article |
| Zdroj: | Croatian Medical Journal Volume 62 Issue 1 |
| ISSN: | 0353-9504 1332-8166 |
| Popis: | Aim: To evaluate liver stiffness (LS) by real-time two-dimensional shear wave elastography (RT 2D-SWE) and to assess its correlation with the mean arterial pressure (MAP) in patients on maintenance hemodialysis (MHD).The secondary aim was to identify biological and biochemical parameters associated with elevated LS. Methods: This study enrolled patients treated with MHD in the Split University Hospital from December 2017 through February 2018. LS was measured after a HD session using RT 2D-SWE. Mean arterial pressure was measured before RT-2D-SWE was performed. Results: The study enrolled 47 patients with the mean +/- standard deviation age of 68.48 +/- 14.33 years. Arterial hypertension was diagnosed in 70.2% of patients. Liver stiffness >7 kPa, suggesting clinically relevant fibrosis, was found in 59.5% of patients. Arterial pressure was significantly correlated with LS (rho=0.38, P-0.008). C-reactive protein (rho = 0.548, P= 0.023), parathyroid hormone (rho =0.507, P=0.038), and total bilirubin (rho = 0.423, P= 0.020) were correlated with elevated LS. Conclusion: Mean arterial pressure is correlated with increased LS in patients on MHD. Our results emphasize the importance of proper regulation of arterial blood pressure and indicate that LS should always be interpreted in combination with laboratory parameters. Further prospective studies with larger series are needed. |
| Databáze: | OpenAIRE |
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