Enhanced contrast acoustic-resolution photoacoustic microscopy using double-stage delay-multiply-and-sum beamformer for vasculature imaging

Autor: Moein Mozaffarzadeh, Manojit Pramanik, Martin D. Verweij, Arunima Sharma, Nico de Jong, Mehdi Haji Heidari Varnosfaderani
Přispěvatelé: Cardiology, School of Chemical and Biomedical Engineering
Rok vydání: 2019
Předmět:
Chemical engineering::Biochemical engineering [Engineering]
Image formation
Depth of focus
Materials science
media_common.quotation_subject
virtual source
General Physics and Astronomy
Neovascularization
Physiologic
Contrast Enhancement
Signal-To-Noise Ratio
01 natural sciences
General Biochemistry
Genetics and Molecular Biology
Imaging phantom
010309 optics
Photoacoustic Techniques
Rats
Sprague-Dawley
Optics
Acoustic-resolution Photoacoustic Microscopy
Full Article
0103 physical sciences
Image Processing
Computer-Assisted
Contrast (vision)
Animals
General Materials Science
acoustic-resolution photoacoustic microscopy
media_common
Microscopy
synthetic aperture focusing technique
business.industry
010401 analytical chemistry
Resolution (electron density)
Ultrasound
Full Articles
General Engineering
General Chemistry
Acoustics
vasculature imaging
0104 chemical sciences
Numerical aperture
Transducer
contrast enhancement
Female
business
acoustic‐resolution photoacoustic microscopy
Zdroj: Journal of Biophotonics
Journal of Biophotonics, 12(11)
Journal of Biophotonics. Wiley-VCH
ISSN: 1864-063X
Popis: In acoustic‐resolution photoacoustic microscopy (AR‐PAM) systems, the lateral resolution in the focal zone of the ultrasound (US) transducer is determined by the numerical aperture (NA) of the transducer. To have a high lateral resolution, a large NA is used. However, the larger the NA, the smaller the depth of focus [DOF]. As a result, the lateral resolution is deteriorated at depths out of the focal region. The synthetic aperture focusing technique (SAFT) along with a beamformer can be used to improve the resolution outside the focal region. In this work, for image formation in AR‐PAM, we propose the double‐stage delay‐multiply‐and‐sum (DS_DMAS) algorithm to be combined with SAFT. The proposed method is evaluated experimentally using hair targets and in vivo vasculature imaging. It is shown that DS_DMAS provides a higher resolution and contrast compared to other methods. For the B‐mode images obtained using the hair phantom, the proposed method reduces the average noise level for all the depths by about 134%, 57% and 23%, compared to the original low‐ resolution, SAFT+DAS and SAFT+DMAS methods, respectively. All the results indicate that the proposed method can be an appropriate algorithm for image formation in AR‐PAM systems.
For image formation in acoustic‐resolution photoacoustic microscopy, double‐stage delay‐multiply‐and‐sum (DS_DMAS) beamforming algorithm is introduced. The proposed method is experimentally evaluated for in vivo vasculature imaging. As shown in the figure, DS_DMAS provides a higher resolution and contrast compared to other methods. (D) Has a lower average noise level for all the depths by about 134%, 57% and 23%, compared to A‐C, respectively.
Databáze: OpenAIRE
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