CD27-CD70 interaction: unravelling its implication in normal and neoplastic B-cell growth
| Autor: | R. Q. Hintzen, Koopman G, Lens Sm, van Lier Ra, de Jong R, van Oers Rh |
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| Rok vydání: | 1995 |
| Předmět: |
Cancer Research
Lymphoma B-Cell medicine.medical_treatment Biology Antigen Antigens CD medicine Leukemia B-Cell Humans B cell CD70 B-Lymphocytes Cell growth Membrane Proteins hemic and immune systems Hematology medicine.disease Transmembrane protein Cell biology Tumor Necrosis Factor Receptor Superfamily Member 7 Leukemia Cytokine medicine.anatomical_structure Oncology Tumor necrosis factor alpha Cell Division CD27 Ligand |
| Zdroj: | Leukemialymphoma. 18(1-2) |
| ISSN: | 1042-8194 |
| Popis: | Members of the Tumour Necrosis Factor-Receptor (TNFR) family play an essential role in the control of lymphoid cell growth and differentiation. The ligand of one of its lymphoid-specific members, CD27, was recently characterized as CD70, a type II transmembrane molecule with homology to TNF that is expressed on activated T and B cells. Ligation of CD27 by its natural ligand generates a potent costimulatory signal for cytokine production and proliferation of activated T cells. In contrast to normal B cells, where CD27 expression is confined to germinal centre cells and to a small subset of circulating B lymphocytes, CD27 expression is found on a large array of distinct B-cell neoplasia. Here, we review recent data on the expression and function of TNFR family members on normal and malignant lymphocytes and propose a role for CD27-CD70 interaction in B-cell development. |
| Databáze: | OpenAIRE |
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