ANCA-associated vasculitis and IgG4-related disease overlap syndrome: a case report and literature review

Autor: David Faz-Muñoz, Andrea Hinojosa-Azaola, Juan M. Mejía-Vilet, Norma O. Uribe-Uribe, Marina Rull-Gabayet, Wallace Rafael Muñoz-Castañeda, Nancy Janeth Vargas-Parra, Eduardo Martín-Nares
Rok vydání: 2022
Předmět:
Zdroj: Immunologic Research. 70:550-559
ISSN: 1559-0755
0257-277X
Popis: Anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitides are infrequent autoimmune diseases characterized by inflammation of the walls of small vessels leading to tissue and endothelial damage. On the other hand, IgG4-related disease is a fibroinflammatory disease characterized histologically by lymphoplasmacytic infiltrates with IgG4+ plasma cells, storiform fibrosis, and obliterative phlebitis that may affect nearly every organ of the body. There are similarities in clinical, serological, radiological, and histopathological features between both diseases, and hence, they usually mimic each other complicating the differential diagnosis. Furthermore, reports of patients with the coexistence of both conditions (overlap syndrome) have been reported. We herein report a patient with an unequivocal diagnosis of ANCA-associated vasculitis, specifically granulomatosis with polyangiitis (posterior uveitis, polyneuropathy, pauci-immune glomerulonephritis with crescent formation and granulomas, and MPO-ANCA positivity) and IgG4-related disease (thoracic aortitis, tubulointerstitial nephritis with prominent IgG4+ plasma cell infiltration, fibrosis, and obliterative arteritis, high levels of serum IgG4, and eosinophilia) overlap syndrome.
Databáze: OpenAIRE
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