Surgical Trauma-induced CCL2 Upregulation Mediates Lung Cancer Progression by Promoting Treg Recruitment in Mice and Patients
| Autor: | Kaibin Zhu, Xiaoyu Zheng, Yubo Yan, Jinfeng Ning, Jianlong Bu, Jian Zhang, Xidong Zhu, Shidong Xu, Su Zhao, Mengfeng Liu |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Cancer Research Lung Neoplasms medicine.medical_treatment CCL2 T-Lymphocytes Regulatory Mice Downregulation and upregulation Carcinoma Non-Small-Cell Lung Surgical removal medicine Animals Humans Lung cancer Chemokine CCL2 Aged business.industry Cancer Immunosuppression General Medicine Middle Aged medicine.disease Up-Regulation Gene Expression Regulation Neoplastic Thoracotomy Oncology A549 Cells Case-Control Studies Disease Progression Cancer research Female business Neoplasm Transplantation |
| Zdroj: | Cancer Investigation. 40:91-102 |
| ISSN: | 1532-4192 0735-7907 |
| Popis: | Surgical removal of the tumor is currently the first-line treatment for lung cancer, but the procedure may accelerate cancer progression through immunosuppression. However, whether CCL2 (C-C motif chemokine ligand 2) enhances cancer progression by affecting regulatory T cells (Tregs) remains unknown. We found that the volume and weight of tumors were larger in the surgical trauma group than in the control group. CCL2 expression and Treg abundance were increased in tumor tissues after surgical trauma, and CCL2 expression was positively associated with Treg abundance. These results demonstrated that surgical trauma contributes to lung cancer progression by increasing CCL2 expression, thus promoting Treg recruitment. |
| Databáze: | OpenAIRE |
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