Oxidative stress and antioxidant defenses in ethanol-induced cell injury
| Autor: | Osvaldo R. Koch, Stella M. Farre, Amerys Cravero, Renata Colavitti, Giovanni Pani, Silvia Borrello, Tommaso Galeotti |
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| Rok vydání: | 2004 |
| Předmět: |
Alcoholic liver disease
Antioxidant medicine.medical_treatment Radical Clinical Biochemistry Oxidative phosphorylation Mitochondrion medicine.disease_cause Biochemistry Antioxidants medicine Animals Humans Liver Diseases Alcoholic Molecular Biology Free-radical theory of aging chemistry.chemical_classification Reactive oxygen species Ethanol General Medicine medicine.disease Oxidative Stress chemistry Molecular Medicine Tumor Suppressor Protein p53 Oxidative stress |
| Zdroj: | Molecular Aspects of Medicine. 25:191-198 |
| ISSN: | 0098-2997 |
| DOI: | 10.1016/j.mam.2004.02.019 |
| Popis: | Although in the past several mechanisms and factors have been proposed to be responsible for alcoholic liver disease (ALD), at present the involvement of oxygen free radicals and consequently of oxidative stress has acquired remarkable credit. In numerous experimental studies it has been shown the occurrence of alcohol-induced generation of oxygen- and ethanol-derived free radicals through different pathways and from different sources. Mitochondria appear to be both an important source of reactive oxygen species (ROS) and also a primary target of ethanol-induced damage. The consistent induction of the mitochondrial antioxidant enzyme manganese superoxide dismutase (Mn-SOD) observed in experimental animals after acute and chronic ethanol administration has all the characteristics of a "stress response" to an oxidative insult. |
| Databáze: | OpenAIRE |
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