Preparing for rotavirus vaccine introduction - A retrospective assessment of the epidemiology of intussusception in children below 2 years of age in Nepal
| Autor: | Jacqueline E. Tate, Ajit Rayamajhi, Anupama Thapa, Umesh D. Parashar, Catherine Yen, Manoj Kumar, Anjana Karki Rayamajhi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Diarrhea
Male Pediatrics medicine.medical_specialty Abdominal pain 030231 tropical medicine medicine.disease_cause Article Rotavirus Infections 03 medical and health sciences 0302 clinical medicine Nepal Rotavirus Intussusception (medical disorder) Epidemiology medicine Humans 030212 general & internal medicine Retrospective Studies General Veterinary General Immunology and Microbiology business.industry Immunization Programs Medical record Vaccination Public Health Environmental and Occupational Health Infant Newborn Rotavirus Vaccines Infant Retrospective cohort study medicine.disease Rotavirus vaccine Hospitalization Infectious Diseases Molecular Medicine Female medicine.symptom business Intussusception |
| Zdroj: | VACCINE |
| Popis: | BACKGROUND: Rotavirus is the most common cause of severe diarrhea in Nepali children, accounting for 25%−33% of childhood diarrhea hospitalizations. Two rotavirus vaccines recommended for inclusion in national immunization programs have been associated with a low risk of intussusception in post-marketing studies conducted in several countries. Data on the epidemiology of intussusception hospitalizations are lacking in Nepal. Thus, we aimed to describe the epidemiology of intussusception-associated hospitalizations among Nepali children in preparation for rotavirus vaccine introduction. METHODS: A retrospective review of intussusception hospitalizations for a three year period was conducted at two major pediatric hospitals in Kathmandu, Nepal. Possible intussusception cases were identified through admission, discharge, and operation theater logs and ultrasound registers. Cases with a diagnosis of possible intussusception were selected for medical record review and classified as confirmed if they met the Brighton Collaboration level 1 criteria of diagnostic certainty and the child was aged |
| Databáze: | OpenAIRE |
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