Safety and optimal protocol of provocation test for diagnosis of multivessel coronary spasm
| Autor: | Yasuhiro Sasaki, Shozo Sueda, Toru Miyoshi, Tomoki Sakaue, Hiroaki Kohno, Hirokazu Habara |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Vasodilator Agents Provocation test Myocardial Ischemia Coronary Vasospasm 030204 cardiovascular system & hematology Coronary Angiography Risk Assessment 03 medical and health sciences 0302 clinical medicine Left coronary artery Predictive Value of Tests Risk Factors medicine.artery Internal medicine medicine Humans Vasoconstrictor Agents cardiovascular diseases 030212 general & internal medicine Ergonovine Aged Retrospective Studies business.industry Middle Aged Vascular surgery Coronary Vessels Acetylcholine Cardiac surgery medicine.anatomical_structure Injections Intra-Arterial Vasoconstriction Anesthesia Right coronary artery Cardiology Female Patient Safety Cardiology and Cardiovascular Medicine business Artery Hemodynamic instability |
| Zdroj: | Heart and Vessels. 31:137-142 |
| ISSN: | 1615-2573 0910-8327 |
| DOI: | 10.1007/s00380-014-0591-7 |
| Popis: | We examined the safety of acetylcholine (ACh) and ergonovine (ER) tests retrospectively and investigated the optimal protocol of provocation test for diagnosis of multivessel coronary spasm. We performed 1546 ACh tests and 1114 ER tests during 23 years. ACh was injected in incremental doses of 20/50/80 μg into the right coronary artery (RCA) and of 20/50/100/200 μg into the left coronary artery (LCA) over 20 s. ER was administered in total doses of 40 μg into the RCA and of 64 μg into the LCA over 2–4 min. When a coronary spasm was induced and did not resolve spontaneously within 3 min after the completion of ACh/ER injection, or when hemodynamic instability due to coronary spasms occurred, 2.5–5.0 mg of nitrate was administered into the responsible vessel. To relive provoked spasm, it is necessary to administer nitrate in 31 cases by ACh and in 76 cases by ER (2.0 vs. 6.8 %, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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