Trends of Mycobacterium bovis Isolation and First-Line Anti-tuberculosis Drug Susceptibility Profile: A Fifteen-Year Laboratory-Based Surveillance
| Autor: | Narciso Ortiz-Conchi, Carmen Cinta-Severo, Bárbara Chávez-Mazari, Brenda Crabtree-Ramírez, Luis Rodríguez-Cruz, Axel Cervantes-Sánchez, Areli Martínez-Gamboa, José Sifuentes-Osornio, Alfredo Ponce de León, Miguel E. Cervera-Hernandez, Pedro Torres-González, Miriam Bobadilla-del Valle, Tomasa Gudiño-Enriquez |
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| Rok vydání: | 2015 |
| Předmět: |
lcsh:Arctic medicine. Tropical medicine
Tuberculosis Isolation (health care) lcsh:RC955-962 Antitubercular Agents Microbial Sensitivity Tests Microbiology Tertiary Care Centers Mycobacterium tuberculosis Pharmacotherapy Tuberculosis Multidrug-Resistant Prevalence Humans Medicine Mexico Mycobacterium bovis biology Transmission (medicine) business.industry lcsh:Public aspects of medicine Zoonosis Public Health Environmental and Occupational Health Extensively drug-resistant tuberculosis lcsh:RA1-1270 Laboratories Hospital biology.organism_classification medicine.disease Virology Infectious Diseases Population Surveillance business Research Article |
| Zdroj: | PLoS Neglected Tropical Diseases, Vol 9, Iss 9, p e0004124 (2015) PLoS Neglected Tropical Diseases |
| ISSN: | 1935-2735 |
| DOI: | 10.1371/journal.pntd.0004124 |
| Popis: | Background Mycobacterium tuberculosis causes the majority of tuberculosis (TB) cases in humans; however, in developing countries, human TB caused by M. bovis may be frequent but undetected. Human TB caused by M. bovis is considered a zoonosis; transmission is mainly through consumption of unpasteurized dairy products, and it is less frequently attributed to animal-to-human or human-to-human contact. We describe the trends of M. bovis isolation from human samples and first-line drug susceptibility during a 15-year period in a referral laboratory located in a tertiary care hospital in Mexico City. Methodology/Principal Findings Data on mycobacterial isolates from human clinical samples were retrieved from the laboratory’s database for the 2000–2014 period. Susceptibility to first-line drugs: rifampin, isoniazid, streptomycin (STR) and ethambutol was determined. We identified 1,165 isolates, 73.7% were M. tuberculosis and 26.2%, M. bovis. Among pulmonary samples, 16.6% were M. bovis. The proportion of M. bovis isolates significantly increased from 7.8% in 2000 to 28.4% in 2014 (X 2 trend, p Author Summary Human tuberculosis caused by Mycobacterium bovis (HTBMb) is a lesser-known form of the disease. The main route of transmission of HTBMb is the consumption of unpasteurized dairy products, causing mostly extrapulmonary disease. M. bovis is naturally resistant to pyrazinamide, a drug that allows for a shorter treatment course. Therefore, if M. bovis is not properly identified or if there is resistance to other drugs, proper treatment may be hindered. Most laboratories in developing countries do not routinely perform mycobacterial cultures, and only a few laboratories can identify M. bovis. Therefore, HTBMb cases are believed to be underestimated. We report a large proportion of M. bovis isolates and an increasing isolation trend across time. We report a large proportion of M. bovis isolates from pulmonary samples, suggesting the possibility of human-to-human airborne transmission. Also, we showed that M. bovis isolates were more frequently resistant to streptomycin, perhaps as a result of antibiotic usage in cattle. This work underscores the need for identification to the species level, proper susceptibility testing, as well as a stricter control of bovine tuberculosis. |
| Databáze: | OpenAIRE |
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