Interleukin-6 production by draining lymph node cells following primary contact sensitisation of mice: relationship to the proliferative response
| Autor: | Rebecca J. Dearman, Ian Kimber, R J Debicki, Jayne Hope, Stephen J. Hopkins |
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| Rok vydání: | 1994 |
| Předmět: |
Time Factors
Ratón medicine.medical_treatment T-Lymphocytes Immunology Dose-Response Relationship Immunologic Biology Dermatitis Contact Lymphocyte Activation Lymphocyte Depletion Mice medicine Immunology and Allergy Animals Secretion Interleukin 6 Lymph node Mice Inbred BALB C Cell growth Interleukin-6 Oxazolone General Medicine medicine.anatomical_structure Cytokine biology.protein Female Lymph Lymph Nodes Ex vivo |
| Zdroj: | International archives of allergy and immunology. 103(4) |
| ISSN: | 1018-2438 |
| Popis: | Interleukin-6 (IL-6) production and proliferative responses by draining lymph node cells were studied in mice exposed topically to a series of chemicals. Chemicals with the capacity to induce sensitisation, but not non-sensitisers, promoted both IL-6 production and lymph node cell proliferation ex vivo. The responses exhibited similar kinetics, were dependent upon the dose of topically applied allergen, and correlated significantly. We demonstrate that the main source of IL-6 within draining lymph nodes is not proliferating T lymphocytes. The induction of a strong IL-6 response, and the relationship of this to cellular proliferation indicate that production of this cytokine within the lymph node is closely associated with the induction of contact sensitivity in mice. |
| Databáze: | OpenAIRE |
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