The effect of frequent hemodialysis on nutrition and body composition: Frequent Hemodialysis Network Trial

Autor: John T. Daugirdas, Brett Larive, George A. Kaysen, Tom Greene, Robert M. Lindsay, Glenn M. Chertow, Yoshio N. Hall, Ravindra L. Mehta, Tom Depner
Rok vydání: 2012
Předmět:
Male
Time Factors
Kidney Disease
medicine.medical_treatment
Body water
Physiology
Kidney
law.invention
Kidney Failure
Randomized controlled trial
law
FHN Trial Group
Electric Impedance
Hypoalbuminemia
Prospective Studies
Chronic
Prospective cohort study
biology
Middle Aged
Urology & Nephrology
nutrition
Treatment Outcome
Nephrology
randomized controlled trials
Body Composition
Female
Hemodialysis
Dietary Proteins
Glomerular Filtration Rate
Adult
medicine.medical_specialty
Clinical Trials and Supportive Activities
Clinical Sciences
Serum albumin
Renal function
Nutritional Status
Bioengineering
Article
chronic hemodialysis
Body Water
Renal Dialysis
Clinical Research
medicine
Humans
daily hemodialysis
Obesity
Serum Albumin
Aged
Nutrition
business.industry
Body Weight
Albumin
hypoalbuminemia
medicine.disease
United States
Surgery
biology.protein
Kidney Failure
Chronic
business
Biomarkers
Zdroj: Kidney international, vol 82, iss 1
Kidney international
ISSN: 0085-2538
DOI: 10.1038/ki.2012.75
Popis: We investigated the effects of frequency of hemodialysis on nutritional status by analyzing the data in the Frequent Hemodialysis Network Trial. We compared changes in albumin, body weight, and composition among 245 patients randomized to six or three times per week in-center hemodialysis (Daily Trial) and 87 patients randomized to six times per week nocturnal or three times per week conventional hemodialysis, performed largely at home (Nocturnal Trial). In the Daily Trial, there were no significant differences between groups in changes in serum albumin or the equilibrated protein catabolic rate by 12 months. There was a significant relative decrease in predialysis body weight of 1.5 ± 0.2 kg in the six times per week group at 1 month, but this significantly rebounded by 1.3 ± 0.5 kg over the remaining 11 months. Extracellular water (ECW) decreased in the six times per week compared with the three per week hemodialysis group. There were no significant between-group differences in phase angle, intracellular water, or body cell mass (BCM). In the Nocturnal Trial, there were no significant between-group differences in any study parameter. Any gain in 'dry' body weight corresponded to increased adiposity rather than muscle mass but was not statistically significant. Thus, frequent in-center hemodialysis reduced ECW but did not increase serum albumin or BCM while frequent nocturnal hemodialysis yielded no net effect on parameters of nutritional status or body composition.
Databáze: OpenAIRE
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