Effect of Paget's disease of bone (osteitis deformans) on the progression of prostate cancer bone metastasis
| Autor: | B. Tu, Avik Som, M. H. Lee, S. C. Yeung, Shi-Ming Tu, C. J. Logothetis |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
musculoskeletal diseases
Oncology Male Cancer Research Pathology medicine.medical_specialty Time Factors Colorectal cancer Bone Neoplasms Prostate cancer Breast cancer Internal medicine otorhinolaryngologic diseases Medicine Humans Aged bone metastasis business.industry Osteitis Deformans Bone metastasis Prostatic Neoplasms Paget's disease Middle Aged medicine.disease prostate cancer body regions medicine.anatomical_structure Paget's disease of bone Case-Control Studies Clinical Study Bone marrow Skin cancer business hormones hormone substitutes and hormone antagonists |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 |
| Popis: | Background: Patients with prostate cancer tend to die from bone metastases. Until now, no evidence has shown that Paget's disease of bone (PDB) affects the progression of bone metastasis or overall survival of patients with prostate cancer. Methods: We searched our patient database for men who had presented with prostate cancer and PDB between June 1993 and March 2009, and identified best-matched control patients according to stage, grade, age, date of diagnosis, treatment, and race. Results: Among 1346 consecutive patients with prostate cancer diagnosed before 2008, 15 were confirmed to have comorbid PDB. Twenty-six more were identified from the institutional billing search. Including the 41 best-matched controls, our total study population was 82 patients. In the Kaplan–Meier analysis, we estimated median times from diagnosis of prostate cancer to bone metastasis to be 21.5 years for those with PDB and 9.4 years for those without PDB (P=0.044). Median overall survival times were 11.8 and 9.2 years for the two groups, respectively (P=0.008). Conclusion: For the first time, we have obtained evidence that patients with prostate cancer and PDB have delayed time to bone metastases and improved overall survival than do patients with prostate cancer alone. |
| Databáze: | OpenAIRE |
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