Glutathione Peroxidase Levels in Nigerias with Acquired Immunodeficiency Syndrome
| Autor: | A C Edimah, G O Nwobu, E A Nwankwo, P A Onyeyili |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
chemistry.chemical_classification
Aids patients Reactive oxygen species Glutathione peroxidase Human immunodeficiency virus (HIV) Standard methods Biology medicine.disease_cause medicine.disease Asymptomatic Acquired immunodeficiency syndrome (AIDS) chemistry Immunology medicine Hiv patients medicine.symptom |
| Zdroj: | Journal of Medical Laboratory Science; Vol 14, No 1 (2005); 11-13 |
| ISSN: | 1116-1043 |
| DOI: | 10.4314/jmls.v14i1.35311 |
| Popis: | Reactive Oxygen Species (ROS) are produced in large amounts in Human Immunodeficiency Virus (HIV) infection. ROS activates HIV replication and multiplication, causing the production of more ROS through the activation of pro-inflammatory cytokines. Glutathione peroxidase (GPX) which inactivates some species of ROS has not been investigated in HIV patients in our area. In a cross-sectional study, 131 AIDS patients, 79 asymptomatic non-AIDS HIV-antibody positive subjects and 102 HIV-antibody negative controls were investigated by standard methods. Glutathione peroxidase activity in AIDS patients was 1041.7+ 75.5 U/L, HIV asymptomatic 2988.6+ 1193.1U/L and controls 6443.3 + 1473.1 U/L. Differences in the results between the groups were statistically significant (p Keywords :Glutathione peroxidase, AIDS, Nigerian Adults Journal of Medical Laboratory Sciences Vol. 14 (1) 2005: pp. 11-13 |
| Databáze: | OpenAIRE |
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