COVID-19 impact on the liver
| Autor: | Lucreția Anghel, Alina Viorica Iancu, Nicușor Baroiu, Liliana Baroiu, Ana-Cristina Leșe, Miruna Draganescu, Caterina Dumitru |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Bilirubin Inflammation Liver injury Chronic liver disease 03 medical and health sciences chemistry.chemical_compound Drug toxicity 0302 clinical medicine Internal medicine Intensive care medicine Cytopathic effect business.industry Biochemical changes COVID-19 Minireviews General Medicine Hypoxia (medical) medicine.disease Clinical trial chemistry 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology medicine.symptom business Hyper-inflammatory reaction |
| Zdroj: | World Journal of Clinical Cases |
| ISSN: | 2307-8960 |
| Popis: | The coronavirus disease 2019 (COVID-19) pandemic imposed arestructuring of global health systems by rethinking spaces used for the care of these patients and the additions of intensive care, infectious diseases and pneumology departments. This paper provides evidence on the presence of severe acute respiratory syndrome coronavirus 2 in hepatocytes and its direct cytopathic activity, as well as the degree of liver damage due to drug toxicity, inflammation and hypoxia in COVID-19. A review of clinical trials has quantified liver damage through both pathology and biochemistry studies. Additionally, we briefly present the results of a study conducted in our clinic on 849 patients admitted for COVID-19 treatment, of which 31 patients had pre-existing chronic liver disease and 388 patients had values above the normal limit for alanine aminotransferase, aspartate aminotransferase, and total bilirubin. It was observed that patients with abnormal liver tests were significantly statistically older, had more comorbidities and had a higher percentage of unfavourable evolution (death or transfer to intensive care). The conclusion of this paper is that the main causes of liver damage are direct viral aggression, coagulation dysfunction and endothelial damage, and patients with impaired liver function develop more severe forms of COVID-19 which requires special care by a multidisciplinary team that includes a hepatologist. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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