Novel methods for integration and visualization of genomics and genetics data in Alzheimer's disease
| Autor: | Bradley T. Hyman, Gyan Srivastava, Sudeshna Das, Yann Lambert, Timothy Clark, Emily Merrill, Nathan A. Bihlmeyer |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Epidemiology Computer science Genomics Disease Polymorphism Single Nucleotide Article Omics data 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Data visualization Developmental Neuroscience Alzheimer Disease Mitochondrial Precursor Protein Import Complex Proteins Humans Genetic Predisposition to Disease Calcium Signaling Longitudinal Studies Genetics business.industry Calcineurin Health Policy Brain Membrane Transport Proteins Omics Visualization Psychiatry and Mental health Molecular network Focal Adhesion Kinase 2 030104 developmental biology Expression data Neurology (clinical) Geriatrics and Gerontology business 030217 neurology & neurosurgery Genome-Wide Association Study |
| Zdroj: | Alzheimer's & Dementia. 15:788-798 |
| ISSN: | 1552-5279 1552-5260 |
| DOI: | 10.1016/j.jalz.2019.01.011 |
| Popis: | Introduction Numerous omics studies have been conducted to understand the molecular networks involved in Alzheimer's disease (AD), but the pathophysiology is still not completely understood; new approaches that enable neuroscientists to better interpret the results of omics analysis are required. Methods We have developed advanced methods to analyze and visualize publicly-available genomics and genetics data. The tools include a composite clinical-neuropathological score for defining AD, gene expression maps in the brain, and networks integrating omics data to understand the impact of polymorphisms on AD pathways. Results We have analyzed over 50 public human gene expression data sets, spanning 19 different brain regions and encompassing three separate cohorts. We integrated genome-wide association studies with expression data to identify important genes in the pathophysiology of AD, which provides further insight into the calcium signaling and calcineurin pathways. Discussion Biologists can use these freely-available tools to obtain a comprehensive, information-rich view of the pathways in AD. |
| Databáze: | OpenAIRE |
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