Effect of 1,25-dihydroxyvitamin D3 and diltiazem on tissue calcium in uremic rat
| Autor: | Yoshihiko Nishian, Tadayasu Syono, Yoshihiro Takamitsu, Oshi Inagaki, Yosiaki Takenaka, Kiyohiko Nakagawa |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty chemistry.chemical_element Calcium Critical Care and Intensive Care Medicine Kidney Phosphates Rats Sprague-Dawley chemistry.chemical_compound Diltiazem Calcitriol medicine.artery Internal medicine Medicine Animals Aorta Uremia business.industry Myocardium Calcinosis Heart General Medicine Phosphate medicine.disease Calcium Channel Blockers Rats Disease Models Animal medicine.anatomical_structure Endocrinology chemistry Nephrology cardiovascular system business Cholecalciferol Calcification medicine.drug |
| Zdroj: | Renal failure. 17(6) |
| ISSN: | 0886-022X |
| Popis: | The concentration of calcium was measured in the aorta, heart, and kidney of uremic rats treated with 100 ng/kg/day 1,25-dihydroxyvitamin D3 (1,25 D3) or 60 mg/kg/day diltiazem for 12 weeks. The concentration of calcium was increased in the aorta, heart, and kidney of uremic rats, and was further increased by administration of 1,25 D3. The 1,25 D3-induced increase in calcium in the aorta was inhibited by diltiazem, but this effect was not accompanied by a decrease in serum calcium x phosphate products. Diltiazem had no effect on the 1,25 D3-induced increase of calcium in the heart and kidney. Thus, in uremia 1,25 D3 may promote the calcification of the aorta; calcium antagonists may protect against calcification without a reduction in serum calcium x phosphate products. |
| Databáze: | OpenAIRE |
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