The spectral features of EEG responses to transcranial magnetic stimulation of the primary motor cortex depend on the amplitude of the motor evoked potentials
| Autor: | Simone Russo, Maurizio Mariotti, Ulf Ziemann, A. Comanducci, Andrea Pigorini, Matteo Fecchio, Fabio Ferrarelli, Marcello Massimini, Alice Mazza, Federico Resta, Isabella Premoli, Mario Rosanova, Silvia Casarotto, Chiara Camilla Derchi, Simone Sarasso |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Physiology medicine.medical_treatment lcsh:Medicine Stimulation Electroencephalography Nervous System 0302 clinical medicine Parietal Lobe Medicine and Health Sciences lcsh:Science Evoked Potentials Physics Clinical Neurophysiology Cerebral Cortex Brain Mapping Multidisciplinary medicine.diagnostic_test Motor Evoked Potentials 05 social sciences Parietal lobe Motor Cortex Brain Transcranial Magnetic Stimulation Electrophysiology Amplitude medicine.anatomical_structure Bioassays and Physiological Analysis Brain Electrophysiology Female Primary motor cortex Anatomy Motor cortex Research Article Adult Imaging Techniques Neurophysiology Neuroimaging Surgical and Invasive Medical Procedures Research and Analysis Methods Membrane Potential 050105 experimental psychology 03 medical and health sciences Motor system medicine Functional electrical stimulation Humans 0501 psychology and cognitive sciences Transcranial Stimulation Scalp Proprioception Functional Electrical Stimulation lcsh:R Electrophysiological Techniques Biology and Life Sciences Evoked Potentials Motor Intensity (physics) Motor System Transcranial magnetic stimulation 030104 developmental biology lcsh:Q Clinical Medicine Neuroscience Head 030217 neurology & neurosurgery |
| Zdroj: | PLOS ONE PLoS ONE Fecchio, M, Pigorini, A, Comanducci, A, Sarasso, S, Casarotto, S, Premoli, I, Derchi, C C, Mazza, A, Russo, S, Resta, F, Ferrarelli, F, Mariotti, M, Ziemann, U, Massimini, M & Rosanova, M 2017, ' The spectral features of EEG responses to transcranial magnetic stimulation of the primary motor cortex depend on the amplitude of the motor evoked potentials ', PL o S One, vol. 12, no. 9, e0184910 . https://doi.org/10.1371/journal.pone.0184910 PLoS ONE, Vol 12, Iss 9, p e0184910 (2017) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0184910 |
| Popis: | Transcranial magnetic stimulation (TMS) of the primary motor cortex (M1) elicits both electroencephalographic (TMS-evoked EEG potentials, TEPs) and electromyographic (motor-evoked potentials, MEPs) responses. Despite this peculiar feature, the effects of M1 stimulation have never been systematically compared with those of other cortical areas and the influence of muscle activation on TEPs is still largely unknown. The present study explored specific features of TEPs elicited by M1 stimulation and assessed whether these features are influenced by MEP amplitude. To this aim, two separate experiments were performed. In experiment 1, single-pulse TMS was applied on primary motor, prefrontal, premotor and parietal cortices at equivalent intensity and the corresponding TEPs were compared by means of local mean field power and time-frequency spectrum. In experiment 2, we focused on M1 where TMS was delivered at resting motor threshold, thus eliciting MEPs with a wide range of amplitude. Here, TEPs computed from high-MEP and low-MEP trials were compared using the same methods applied in experiment 1. With respect to the other cortical targets, TMS of the motor cortex produced larger TEPs accompanied by a late (~300 ms) event-related desynchronization (ERD). The magnitude of these features was proportional to the amplitude of MEPs as highlighted by the comparison between high-MEP and low-MEP conditions. The larger TEPs amplitude and the presence of a late ERD are hallmarks of the primary motor cortex stimulation. These results might reflect specific anatomo-functional features of the motor cortex including the proprioceptive feedback produced by muscle activation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|