Reduced life expectancy in rats after neonatal dexamethasone treatment
| Autor: | Annemieke Kavelaars, Patrick Joseph Gerardus Hendrikus Kamphuis, Marguerite E.I. Schipper, Frank van Bel, Cobi Jacoba Johanna Heijnen, Jaap E. van Dijk, Victor M. Wiegant, Willem B. de Vries, Matthijs F.M. van Oosterhout, Gerda Croiset, J.G.M. Bakker |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Longevity Physiology Disease Dexamethasone Life Expectancy Internal medicine medicine Animals Young adult Rats Wistar Glucocorticoids business.industry Rats Steroid hormone Endocrinology Animals Newborn Lung disease Pediatrics Perinatology and Child Health Hypertension Life expectancy Corticosteroid Female business Glucocorticoid medicine.drug |
| Zdroj: | Pediatric research. 61(1) |
| ISSN: | 0031-3998 |
| Popis: | The glucocorticoid dexamethasone (Dex) is widely used in preterm infants for the prevention of chronic lung disease. However, major concern has arisen about the long-term sequelae of this therapy. Here we report that neonatal treatment with dexamethasone significantly shortens the lifespan by 25% of male rats (28.6 +/- 1.1 to 21.3 +/- 0.8 mo) and by 18% of female rats (26.9 +/- 1.8 to 22.0 +/- 0.7 mo). Histopathological examination indicated end-stage cardiac and renal failure as the cause of premature death. Furthermore, Dex-treated rats showed symptoms of hypertension at young adult age, which worsened with increasing age. Thus, a brief period of glucocorticoid treatment during early life results in untimely death presumably due to cardiovascular and renal disease later in life. These serious, adverse long-term consequences call for prudence with glucocorticoid treatment of human preterm infants and careful follow-up of young adults with a history of neonatal glucocorticoid treatment. |
| Databáze: | OpenAIRE |
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