The glucose and nitrogen starvation response ofBacillus licheniformis
| Autor: | Stefan Evers, Thomas Schweder, Birgit Voigt, Birgit Veith, Karl-Heinz Maurer, Le Thi Hoi, Michael Hecker, Dirk Albrecht, Armin Ehrenreich, Britta Jürgen |
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| Rok vydání: | 2007 |
| Předmět: |
2. Zero hunger
chemistry.chemical_classification 0303 health sciences Proteome Nitrogen 030306 microbiology Nitrogen deficiency Bacillus Metabolism Biology Carbohydrate metabolism biology.organism_classification Biochemistry Amino acid Transcriptome 03 medical and health sciences Glucose chemistry Bacillus licheniformis Starvation response Molecular Biology Bacteria 030304 developmental biology |
| Zdroj: | PROTEOMICS. 7:413-423 |
| ISSN: | 1615-9861 1615-9853 |
| DOI: | 10.1002/pmic.200600556 |
| Popis: | The glucose and nitrogen starvation stimulons of Bacillus licheniformis were determined by transcriptome and proteome analyses. Under both starvation conditions, the main response of B. licheniformis was a switch to the usage of alternative nutrient sources. This was indicated by an induction of genes involved in the metabolism of C-2 substrates during glucose limitation. In addition, B. licheniformis seems to be using other organic substances like amino acids and lipids as carbon sources when subjected to glucose starvation. This observation is supported by the induction of a high number of genes coding for proteins involved in amino acid and lipid degradation. During nitrogen starvation, genes for several proteases and peptidases involved in nitrate and nitrite assimilation were induced, which enables this bacterium to recruit nitrogen from alternative sources. Both starvation conditions led to a down-regulation of transcription of most vegetative genes, which was subsequently reflected by a reduced synthesis of the corresponding proteins. A selected set of genes was induced by both starvation conditions. Among them were yvyD, citA and the putative methylcitrate shunt genes mmgD, mmgE and yqiQ. However, both starvation conditions did not induce a general SigmaB-dependent stress response. |
| Databáze: | OpenAIRE |
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