Turnover of circulating virion RNA and of cell-associated viral DNA reflects active viral replication in human immunodeficiency virus type 1-infected individuals
| Autor: | J A Waterbury, S. Staszewski, Joseph Kessler, D W Lineberger, Emilio A. Emini, V W Byrnes, F. E. Massari |
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| Rok vydání: | 1995 |
| Předmět: |
Pyridones
viruses Immunology RNA-dependent RNA polymerase HIV Infections Viral transformation Biology Virus Replication Antiviral Agents Microbiology Viral entry Virology Humans Viral shedding Benzoxazoles Cell-Free System Virion RNA RNA-Directed DNA Polymerase HIV Reverse Transcriptase Reverse transcriptase Cell Compartmentation Viral replication Insect Science DNA Viral HIV-1 RNA Viral Reverse Transcriptase Inhibitors Viral load Research Article |
| Zdroj: | Journal of Virology. 69:2637-2639 |
| ISSN: | 1098-5514 0022-538X |
| Popis: | A quantitative assessment of human immunodeficiency virus type 1 turnover in patient cell-free virion and infected-cell compartments under the dynamic conditions imposed by an effective antiviral therapy was performed. The turnover was rapid, and following a temporal lag, the extent of viral population replacement was eventually similar in both compartments. Each compartment therefore reflects considerable active virus replication. |
| Databáze: | OpenAIRE |
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