Speckled (particulate) epidermal nuclear IgG deposition in normal skin. Correlation of clinical features and laboratory findings in 46 patients with a subset of connective tissue disease characterized by antibody to extractable nuclear antigen
| Autor: | Denny L. Tuffanelli, Stephen D. Prystowsky |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Extractable nuclear antigens Fluorescent Antibody Technique Dermatology Skin Diseases Scleroderma Scleroderma Localized Lupus Erythematosus Discoid Sicca syndrome medicine Humans Antigens skin and connective tissue diseases Direct fluorescent antibody Aged Skin Cell Nucleus Lupus erythematosus integumentary system business.industry Collagen Diseases Sclerodactyly General Medicine Middle Aged Dermatomyositis medicine.disease Connective tissue disease Connective Tissue Antibodies Antinuclear Immunoglobulin G Immunology Female medicine.symptom business |
| Zdroj: | Archives of Dermatology. 114:705-710 |
| ISSN: | 0003-987X |
| DOI: | 10.1001/archderm.114.5.705 |
| Popis: | • Clinical and laboratory findings were correlated from 46 patients with IgG localization in epidermal nuclei in a speckled (particulate) pattern on direct immunofluorescence of normal skin. Cutaneous manifestations included lupus erythematosus (LE), swollen hands or sclerodactyly, alopecia, vasculitis, and dyspigmentation. Systemic manifestations included arthritis or arthralgia, Raynaud's phenomenon, serositis, vascular headaches, mild renal disease, myositis, and sicca syndrome. High titer (mean = 1:142, 800) serum antibody to extractable nuclear antigen (ENA) was found in 81%. Eighty-six percent had antibody to an RNase-sensitive antigenic component of ENA (ribonucleoprotein or RNP); 14% had antibody to an RNase-resistant ENA termed Sm. Deposition of IgG in a speckled pattern in epidermal nuclei is an immunopathologic marker for a subset of connective tissue disease characterized by antibody to ENA. Those with Sm specificity had systemic LE (SLE). Those with RNP specificity had Raynaud's phenomenon usually associated with overlapping features of SLE, scleroderma, and/or dermatomyositis. ( Arch Dermatol 114:705-710, 1978) |
| Databáze: | OpenAIRE |
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