Tissue glycolytic and gluconeogenic enzyme activities in mildly and moderately diabetic rats: influence of tolbutamide administration
| Autor: | James W. Anderson, E. Dennis Murphy |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Kidney Cortex Renal cortex Tolbutamide Biology Endocrinology Diabetes mellitus Internal medicine Glucokinase medicine Diabetes Mellitus Animals Glycolysis Intestinal Mucosa chemistry.chemical_classification Muscles Myocardium Body Weight Gluconeogenesis Organ Size medicine.disease Rats medicine.anatomical_structure Enzyme Jejunum chemistry Liver Phosphoenolpyruvate Carboxykinase (GTP) Phosphoenolpyruvate carboxykinase Phosphoenolpyruvate carboxylase medicine.drug |
| Zdroj: | Endocrinology. 94(1) |
| ISSN: | 0013-7227 |
| Popis: | Mild diabetes (blood glucose < 300 mg/100 ml) was associated with a significant reduction in hepatic glucokinase suggesting that this enzyme is the most sensitive glycolytic enzyme indicator of the diabetic state since no other tissue enzyme alterations were noted. Moderate diabetes (blood glucose, 300−500) was accompanied by glycolytic enzyme values which were significantly decreased in liver and skeletal muscles, values which were significantly increased in renal cortex, and values which were similar to control values in jejunal mucosa and heart. Thus each of these five tissues had a specific adaptive response to the diabetic state. Phosphoenolpyruvate carboxykinase was significantly increased in liver of mildly diabetic rats and in renal cortex of moderately diabetic rats. This enzyme appears to be the most sensitive gluconeogenic enzyme indicator of the diabetic state and also shows the greatest percentage increase observed for the rate-limiting gluconeogenic enzymes in livers of diabetic animals. Tol... |
| Databáze: | OpenAIRE |
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