Effects of fetal septal grafts on memory and learning performance with hippocampal acetylcholine and choline metabolism in fimbria transected rats
| Autor: | Ismail H. Ulus, L Büyükuysal, S Z Ipekoğlu, Ender Korfali |
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| Přispěvatelé: | Uludağ Üniversitesi/Tıp Fakültesi/Nöroşirurji Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı., İpekoğlu, S. Z., Büyükuysal, Levent, Ulus, İsmail Hakkı, Korfalı, Ender, D-5340-2015 |
| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
Fornix
Brain Hippocampus Fimbria Deficits Water maze Hippocampal formation Monkeys Neural transplantation Motor activity Animal tissue Choline Rats Sprague-Dawley Recovery Medicine Brain injury Priority journal Neurons Fornix Brain Anatomy Brain tissue Denervation Maze test Psychiatry and Mental health Tissue graft Cholinergic Fibers Neurology Clinical neurology Female medicine.symptom Animal cell Acetylcholine medicine.drug medicine.medical_specialty Fornix lesions 192 Igg-Saporin Cholinergic Neurons Basal Forebrain Scopolamine In Vitro Techniques Neurosciences & neurology Article Lesion Fetus Tissue level Memory Internal medicine Impairments Avoidance Learning Animals Learning Animal model Animal experiment Cholinergic neuron Maze Learning Biological Psychiatry Nucleus basalis magnocellularis Behavior business.industry Avoidance behavior Neurosciences Nonhuman Rats Transplantation Endocrinology Forebrain Rat Septal Nuclei Neurology (clinical) business Brain tissue transplantation Controlled study |
| Popis: | Female Sprague-Dawley rats underwent aspirative lesion of the fimbria to produce septohippocampal disconnection. Two weeks after the lesion surgery, fetal septal grafts prepared from ventral forebrain of 13-15 days old fetuses of the same outbred strain were placed into the lesion cavity (grafted group). Three months after grafting, all rats were tested for spontaneous motor activity (SMA), step through passive avoidance (STPA) and in Morris' water maze (MWM). Six months after grafting, both basal and stimulated acetylcholine (ACh) and choline (Ch) release and their tissue levels were measured in ipsilateral hippocampal slices. Septohippocampal disconnection caused a significant impairment in Morris' water maze tasks, but did not alter spontaneous motor activity and step through passive avoidance. Fimbrial lesion, moreover, also declined both stimulated ACh release and tissue ACh levels in hippocampal slices. While lesion-induced change in Morris' water maze was ameliorated partially, declines in both stimulated ACh release and tissue ACh levels were raised to the control levels by fetal septal graft placed into the lesion cavity. These data show that grafted cholinergic neurons can work biochemically which may not result with a complete behavioral amelioration which is, in fact something more complex. |
| Databáze: | OpenAIRE |
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