Inflammatory cellular kinetics in sympathetic ophthalmia a study of 29 traumatized (exciting) eyes
| Autor: | Chi-Chao Chan, Ian W. McLean, Robert B. Nussenblatt, Michael A. Piacentini, Dev N. Shah, Miguel Burnier |
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| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.drug_class business.industry Sympathetic ophthalmia T cell T lymphocyte Monoclonal antibody medicine.disease MHC class II antigen Ophthalmology medicine.anatomical_structure Immunology medicine Immunology and Allergy Immunohistochemistry sense organs business Pathological B cell |
| Zdroj: | Ocular immunology and inflammation. 1(3) |
| ISSN: | 0927-3948 |
| Popis: | An immunohistochemical study was conducted on 29 cases of sympathetic ophthalmia (SO). Monoclonal antibodies against T, B, NK cells, macrophages, and MHC class II antigen (HLA-DR) were used. The choroidal infiltrate in 20 eyes was predominantly T cell while B cell predominated in four cases. All eyes with a B cell predominance came from males. A predominance of B cells was correlated to a longer duration of the disease (> 9 months) and in eyes showing phthisical changes. There was no correlation between a predominance of B cells with age, race, corticosteroid treatment or histological type (typical or atypical). These findings suggest that, although SO is a T cell mediated disease, the predominance of B cells in some cases may represent the end stage of the disease process, or seems a secondary pathological process. The kinetic change in cell populations during the disease may have therapeutic implication. |
| Databáze: | OpenAIRE |
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