THE SIGNIFICANCE OF INDUCED FORESTOMACH TUMORS
| Autor: | Frank Iverson, E. Lok, David B. Clayson, E.A. Nera |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Food industry
Food spoilage Population Butylated Hydroxyanisole Physiology Biology Toxicology medicine.disease_cause chemistry.chemical_compound Stomach Neoplasms Chemical carcinogens medicine Animals Humans Animal body education Carcinogen Pharmacology education.field_of_study business.industry stomatognathic diseases chemistry Carcinogens Butylated hydroxyanisole business Carcinogenesis |
| Zdroj: | Annual Review of Pharmacology and Toxicology. 30:441-463 |
| ISSN: | 1545-4304 0362-1642 |
| DOI: | 10.1146/annurev.pa.30.040190.002301 |
| Popis: | Scientific interest in forestomach carcinogenesis has been greatly heightened by the observation that butylated hydroxyanisole (BHA) is carcinogenic to rats at this site (1). BHA is one of only three synthetic phenolic antioxidants that are permitted to be added to food in Canada. These chemicals inhibit oxidative spoilage of food (rancidity) during transportation and storage and are thus of importance to the functioning of the modern centralized food industry. The demonstration that high levels of BHA incorporated into the food of male and female rats resulted in papillomas and carcinomas of the forestomach led to an international research effort focused on the forestomach and designed to outline the way in which these tumors arose and determine whether they are relevant to humans (2). This report addresses the development of cancerous lesions in the rodent forestomach, the nature of the chemicals that induce these lesions, and their interactions with the animal body. Presently available evidence indicates there are at least two different types of chemical carcinogen that act on the forestomach and that these may have very different degrees of relevance to the human population. |
| Databáze: | OpenAIRE |
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