Systemic sclerosis: an autoantibody mosaic

Autor:	C C Bunn, Carol M. Black
Rok vydání:	1999
Předmět:	Pathology medicine.medical_specialty Scleroderma Systemic Editorial Review integumentary system business.industry Immunology Autoantibody Disease medicine.disease Trunk Polymyositis Scleroderma Antibody Specificity Fibrosis medicine Animals Humans Immunology and Allergy business Autoantibodies
Zdroj:	Clinical and Experimental Immunology. 117:207-208
ISSN:	1365-2249 0009-9104
DOI:	10.1046/j.1365-2249.1999.00990.x
Popis:	Systemic sclerosis (SSc) is a disease characterized by collagen deposition and subsequent fibrosis in skin and internal organs. The extent of fibrosis shows considerable variation in severity, leading to a classification that divides the disease into two main categories: the limited cutaneous form, primarily affecting skin distal to the knees and elbows, and the diffuse form also affecting skin on the trunk [1]. Additionally, SSc can coexist with other autoimmune rheumatic diseases and is frequently associated with polymyositis (PM) as part of the spectrum of overlap syndromes [2]. Serologically, however, several different autoantibodies occur in non-overlapping populations that in general correlate with prognosis and suggest that SSc could be a composite of distinct clinical entities [3–5].
Databáze:	OpenAIRE
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