The Area Under the Concentration-Time Curve Versus Trough and Peak Blood Level Monitoring in Renal Transplant Recipients on Cyclosporine
| Autor: | F. Donia, K.V. Johny, M.A. Halim, M.P. Nair, M. Samhan, M. Al-Mousawi, T. Said, M.R.N. Nampoory, M.H. Hamid, I. Al-Muzairai, M. Mansour |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Adolescent Urinary system Urology chemistry.chemical_compound medicine Humans Child Monitoring Physiologic Transplantation Creatinine Kidney Proteinuria business.industry Histocompatibility Testing Incidence (epidemiology) Area under the curve Ciclosporin Kidney Transplantation Surgery medicine.anatomical_structure chemistry Area Under Curve Child Preschool Cyclosporine Drug Therapy Combination Female medicine.symptom business Immunosuppressive Agents medicine.drug |
| Zdroj: | Transplantation Proceedings. 37:3019-3021 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/j.transproceed.2005.07.061 |
| Popis: | Objective. The area under the concentration-time curve of cyclosporine microemulsion is the best measure of the absorption and beneficial effects in renal transplant recipients. We sought to determine the best method of monitoring cyclosporine levels in these patients. Methods. Prospective evaluation of peak cyclosporine blood levels and area under the curve monitoring were performed for 1 year in 65 renal transplant recipients (study group). Cyclosporine trough levels and peak cyclosporine blood levels were correlated with the calculated area under the curve. Cyclosporine trough levels were monitored in equal numbers of matched controls. Results. There were no significant differences in the incidence of acute rejection, cyclosporine nephrotoxicity, proteinuria, serum creatinine levels, or graft and patient outcomes between the groups (P = .1). Peak cyclosporine blood levels guided by calculating the area under the curve were found to be 27% to 32% lower than previously reported. The correlation coefficient was 90% for peak cyclosporine blood levels (P |
| Databáze: | OpenAIRE |
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