G3BP1 inhibits RNA virus replication by positively regulating RIG-I-mediated cellular antiviral response
| Autor: | Yi Ru, Shaozu Fu, Junshu Wei, Li Dan, Wenping Yang, Jingjing Ren, Juncui Bai, Xiangtao Liu, Haixue Zheng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research viruses Ubiquitin-Protein Ligases Immunology chemical and pharmacologic phenomena Biology Virus Replication Article 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine RNA Virus Infections Humans RNA Viruses lcsh:QH573-671 Receptors Immunologic Poly-ADP-Ribose Binding Proteins Innate immune system lcsh:Cytology RIG-I Pattern recognition receptor DNA Helicases Ubiquitination RNA RNA virus Cell Biology biology.organism_classification Sendai virus Immunity Innate Cell biology 030104 developmental biology RNA Recognition Motif Proteins Gene Expression Regulation Vesicular stomatitis virus Receptors Pattern Recognition Host-Pathogen Interactions RIG-I-like receptors DEAD Box Protein 58 Extracellular signalling molecules Signal transduction 030217 neurology & neurosurgery RNA Helicases Signal Transduction |
| Zdroj: | Cell Death & Disease Cell Death and Disease, Vol 10, Iss 12, Pp 1-15 (2019) |
| ISSN: | 2041-4889 |
| Popis: | Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor and is involved in the innate immune response against RNA viruses infection. Here, we demonstrate that the Ras-GTPase-activating protein SH3-domain-binding protein 1 (G3BP1) serves as a positive regulator of the RIG-I-mediated signaling pathway. G3BP1-deficient cells inhibited RNA virus-triggered induction of downstream antiviral genes. Furthermore, we found that G3BP1 inhibited the replication of Sendai virus and vesicular stomatitis virus, indicating a positive regulation of G3BP1 to cellular antiviral responses. Mechanistically, G3BP1 formed a complex with RNF125 and RIG-I, leading to decreased RNF125 via its auto-ubiquitination; thus, promoting expression of RIG-I. Overall, the results suggest a novel mechanism for G3BP1 in the positive regulation of antiviral signaling mediated by RIG-I. |
| Databáze: | OpenAIRE |
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