Antioxidant effects of Dendropanax morbifera Léveille extract in the hippocampus of mercury-exposed rats
| Autor: | Hyo Young Jung, Dong-Woo Kim, Jung Hoon Choi, Seung Myung Moon, Dae Young Yoo, Jong Whi Kim, Dae Won Kim, Woosuk Kim, Yeo Sung Yoon, In Koo Hwang |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Antioxidant medicine.medical_treatment Intraperitoneal injection Dendropanax morbifera extract Mercury Hippocampus Reactive oxygenspecies Protein modification Antioxidants Rats Sprague-Dawley Lipid peroxidation Superoxide dismutase chemistry.chemical_compound medicine Animals Araliaceae Glutathione Transferase chemistry.chemical_classification Glutathione Peroxidase Reactive oxygen species biology Traditional medicine Plant Extracts Superoxide Dismutase Chemistry Glutathione peroxidase General Medicine Catalase Malondialdehyde Rats Plant Leaves Complementary and alternative medicine Biochemistry biology.protein Lipid Peroxidation Reactive Oxygen Species Research Article |
| Zdroj: | BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE(15) BMC Complementary and Alternative Medicine |
| ISSN: | 1472-6882 |
| DOI: | 10.1186/s12906-015-0786-1 |
| Popis: | Background: Dendropanax morbifera Leveille has been employed for the treatment of infectious diseases using folk medicine. In this study, we evaluated the antioxidant effects of a leaf extract of Dendropanax morbifera Leveille in the hippocampus of mercury-exposed rats. Methods: Seven-week-old Sprague-Dawley rats received a daily intraperitoneal injection of 5 mu g/kg dimethylmercury and/or oral Dendropanax morbifera Leveille leaf extract (100 mg/kg) for 4 weeks. Animals were sacrificed 2 h after the last dimethylmercury and/or leaf extract treatment. Mercury levels were measured in homogenates of hippocampal tissue, a brain region that is vulnerable to mercury toxicity. In addition, we measured reactive oxygen species production, lipid peroxidation levels, and antioxidant levels in these hippocampal homogenates. Results: Treatment with Dendropanax morbifera Leveille leaf extract significantly reduced mercury levels in hippocampal homogenates and attenuated the dimethylmercury-induced increase in the production of reactive oxygen species and formation of malondialdehyde. In addition, this leaf extract treatment significantly reversed the dimethylmercury-induced reduction in the hippocampal activities of Cu, Zn-superoxide dismutase, catalase, glutathione peroxidase, and glutathione-S-transferase. Conclusion: These results suggest that a leaf extract of Dendropanax morbifera Leveille had strong antioxidant effects in the hippocampus of mercury-exposed rats. |
| Databáze: | OpenAIRE |
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