Active surveillance for multidrug-resistant Gram-negative bacteria in the intensive care unit
| Autor: | David L. Paterson, Iain J. Abbott, Adam Jenney, Leisha J. Richardson, Anton Y. Peleg, Hanna E. Sidjabat, David Pilcher, Denis Spelman |
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| Rok vydání: | 2015 |
| Předmět: |
Cross Infection
business.industry Ceftazidime Drug Resistance Microbial Drug resistance Intensive care unit Pathology and Forensic Medicine Microbiology law.invention Cohort Studies Intensive Care Units chemistry.chemical_compound Antibiotic resistance chemistry law Intensive care medicine Humans Gentamicin Screening cultures Gram-Negative Bacterial Infections business MacConkey agar medicine.drug |
| Zdroj: | Pathology. 47:575-579 |
| ISSN: | 0031-3025 |
| Popis: | A short-term program of performing serial active screening cultures (ASC) in the intensive care unit was instituted to establish a method for the detection of antibiotic-resistant Gram-negative bacteria (GNB) and the local rates of colonisation. Of all submitted ASC, 25.9% (30/116 collected swabs) isolated an antibiotic-resistant GNB. ChromID ESBL agar (bioMérieux, France) identified the majority of these organisms, with the additional antibiotic-impregnated media [MacConkey agar (MCA) with ciprofloxacin, MCA with gentamicin and MCA with ceftazidime] adding limited benefit. Compared to swabs performed on admission, 37.8% (14/37) of patients cultured a new antibiotic-resistant isolate on discharge. Serial screening in intensive care has the ability to identify patients with unrecognised colonisation with antibiotic-resistant GNB; however, the increase in the laboratory workload and logistical challenges in the collection of the surveillance swabs may limit this program's expansion. |
| Databáze: | OpenAIRE |
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