Focal Dorsal Hippocampal Nav1.1 Knock Down Alters Place Cell Temporal Coordination and Spatial Behavior
| Autor: | Sophie Sakkaki, Sylvain J. Barriere, Pierre-Pascal Lenck-Santini, Rod C. Scott, Alex C. Bender |
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| Přispěvatelé: | University of Vermont [Burlington], Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Geisel School of Medicine at Dartmouth, Cardiac Unit, Institute of Child Health (UCL), University College of London [London] (UCL), Institut de Neurobiologie de la Méditerranée [Aix-Marseille Université] (INMED - INSERM U1249), Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), Guerineau, Nathalie C., Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université du Vermont, Great Ormond Street Hospital for Children [London] (GOSH) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Cognitive Neuroscience place cell [SDV]Life Sciences [q-bio] Place cell Spatial Behavior Hippocampal formation Inhibitory postsynaptic potential Hippocampus CA1 03 medical and health sciences Cellular and Molecular Neuroscience Epilepsy 0302 clinical medicine medicine Animals Rats Long-Evans [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] AcademicSubjects/MED00385 Nav11 ComputingMilieux_MISCELLANEOUS 030304 developmental biology 0303 health sciences Chemistry AcademicSubjects/SCI01870 Nav1.1 Sodium channel [SCCO.NEUR]Cognitive science/Neuroscience medicine.disease Rats Coupling (electronics) NAV1.1 Voltage-Gated Sodium Channel [SDV] Life Sciences [q-bio] medicine.anatomical_structure Place Cells nervous system SC1NA theta Gene Knockdown Techniques NAV1 AcademicSubjects/MED00310 Original Article [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Pyramidal cell Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Cerebral Cortex Cerebral Cortex, Oxford University Press (OUP), 2020, 30, pp.5049-5066. ⟨10.1093/cercor/bhaa101⟩ Cerebral Cortex, 2020, 30, pp.5049-5066. ⟨10.1093/cercor/bhaa101⟩ Cerebral Cortex (New York, NY) Cerebral Cortex, Oxford University Press (OUP), 2020, ⟨10.1093/cercor/bhaa101⟩ |
| ISSN: | 1047-3211 1460-2199 |
| DOI: | 10.1093/cercor/bhaa101⟩ |
| Popis: | Alterations in the voltage-gated sodium channel Nav.1.1 are implicated in various neurological disorders, including epilepsy, Alzheimer’s disease, and autism spectrum disorders. Previous studies suggest that the reduction of Nav1.1 expression leads to a decrease of fast spiking activity in inhibitory neurons. Because interneurons (INs) play a critical role in the temporal organization of neuronal discharge, we hypothesize that Nav1.1 dysfunction will negatively impact neuronal coordination in vivo. Using shRNA interference, we induced a focal Nav1.1 knock-down (KD) in the dorsal region of the right hippocampus of adult rats. Focal, unilateral Nav1.1 KD decreases the performance in a spatial novelty recognition task and the firing rate in INs, but not in pyramidal cells. It reduced theta/gamma coupling of hippocampal oscillations and induced a shift in pyramidal cell theta phase preference. Nav1.1 KD degraded spatial accuracy and temporal coding properties of place cells, such as theta phase precession and compression of ongoing sequences. Aken together, these data demonstrate that a deficit in Nav1.1 alters the temporal coordination of neuronal firing in CA1 and impairs behaviors that rely on the integrity of this network. They highlight the potential contribution of local inhibition in neuronal coordination and its impact on behavior in pathological conditions. |
| Databáze: | OpenAIRE |
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