The role of the Cellular Antioxidant Defense System on Oxidative Stress in Acute Appendicitis
| Autor: | Ayetullah TEMİZ, Mesut IŞIK, Yavuz ALBAYRAK, Hatice Esra DURAN, Adem ASLAN, Yeliz DEMİR, Ayse ALBAYRAK, Şükrü BEYDEMİR |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Reactive oxygen species Antioxidant Chemistry medicine.medical_treatment Mühendislik Glutathione Malondialdehyde medicine.disease_cause PON1 Lipid peroxidation chemistry.chemical_compound Endocrinology Engineering Acute Perforated Appendicitis Internal medicine medicine Oxidative stress acute appendicitis cellular defense system antioxidant enzyme Oxidative stress |
| Zdroj: | Volume: 49, Issue: 1 69-78 Hacettepe Journal of Biology and Chemistry |
| ISSN: | 2687-475X |
| Popis: | It is known that free radicals, their products and reactive oxygen species (ROS) are associated with many diseases. The study focuses on both some changes in oxidative stress factors in patients with acute appendicitis (AA) and the changes of GST and PON1 enzyme activities in the metabolism. This study involved control group (n = 31) and the study group (n = 52). In the groups, some changes in oxidative stress factors and GST and PON1 enzyme activities which play an important role in metabolism were determined. There are changes in GST activity between study and control groups. The activity of the enzyme were significantly higher in AA groups (p < 0.01) than control. Malondialdehyde (MDA) levels in acute perforated appendicitis (PeA) groups were found significantly higher than control (p |
| Databáze: | OpenAIRE |
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