Incidence and Clinical Features of Venous Thromboembolism in Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) in Japan
| Autor: | Hideki Sakashita, Shizu Aikawa, Shingo Ishiguro, Makoto Mo, Eriko Iwata, Satoshi Ikeda, Sen Yachi, Nobutaka Ikeda, Naoto Yamamoto, Takao Kobayashi, Hirono Satokawa, Akane Kondo, Yoshinori Okuno, Yoshito Ogihara, Yuji Nishimoto, Yugo Yamashita, Yuuki Maruyama, Takehisa Iwai, Michihisa Umetsu, Hiroya Hayashi, Masami Shingaki, Hiroko Nakata, Naoki Toya, Ichizo Tsujino, Norikazu Yamada |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19) Hospitalized patients 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Japan Risk Factors Internal medicine medicine Humans 030212 general & internal medicine Retrospective Studies business.industry Incidence (epidemiology) Incidence COVID-19 General Medicine Venous Thromboembolism medicine.disease Pulmonary embolism Asians Cardiology and Cardiovascular Medicine business Complication Pulmonary Embolism Body mass index Venous thromboembolism Cohort study |
| Zdroj: | Circulation journal : official journal of the Japanese Circulation Society. 85(12) |
| ISSN: | 1347-4820 |
| Popis: | BACKGROUND: Coronavirus disease 2019 (COVID-19) reportedly causes venous thromboembolism (VTE), but the status of this complication in Japan was unclear.MethodsâandâResults:The VTE and COVID-19 in Japan Study is a retrospective, multicenter cohort study enrolling hospitalized patients with COVID-19 who were evaluated with contrast-enhanced computed tomography (CT) examination at 22 centers in Japan between March 2020 and October 2020. Among 1,236 patients with COVID-19, 45 (3.6%) were evaluated with contrast-enhanced CT examination. VTE events occurred in 10 patients (22.2%), and the incidence of VTE in mild, moderate, and severe COVID-19 was 0%, 11.8%, and 40.0%, respectively. COVID-19 patients with VTE showed a higher body weight (81.6 vs. 64.0 kg, P=0.005) and body mass index (26.9 vs. 23.2 kg/m2, P=0.04), and a higher proportion had a severe status for COVID-19 compared with those without. There was no significant difference in the proportion of patients alive at discharge between patients with and without VTE (80.0% vs. 88.6%, P=0.48). Among 8 pulmonary embolism (PE) patients, all were low-risk PE. CONCLUSIONS: Among a relatively small number of patients undergoing contrast-enhanced CT examination in Japanese real-world clinical practice, there were no VTE patients among those with mild COVID-19, but the incidence of VTE seemed to be relatively high among severe COVID-19 patients, although all PE events were low-risk without significant effect on mortality risk. |
| Databáze: | OpenAIRE |
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